o bjectives: heat-polymerized acrylic resin has been the most commonly used denture base material for over 60 years. however, the mechanical strength of acrylic resin is not adequate for long-term clinical performance of dentures. consequently, fracture is a com- mon clinical occurrence, which often occurs in the midline of denture base.this study aimed to evaluate the efficacy of cold cure and...

This paper proposes, for the first time, use of an asymmetric positive and heavy-tailed distribution in a cure rate model context. In particular, it introduces cure-rate survival by assuming that time-to-event interest follows slash half-normal number competing causes event power series distribution, which defines six new models. Several properties are derived alternative expression cumulative ...

We consider nonparametric estimation of cure-rate based on mixture model under Case-1 interval censoring. We show that the nonparametric maximum-likelihood estimator (NPMLE) of cure-rate is non-unique as well as inconsistent , and propose two estimators based on the NPMLE of the distribution function under this censoring model. We present a cross-validation method for choosing a 'cut-off' point...

AIMS The aim of this study was to use data from an experimental induced blood stage malaria clinical trial to characterize the antimalarial activity of the new compound Actelion-451840 using pharmacokinetic/pharmacodynamic (PK/PD) modelling. Then, using simulations from the model, the dose and dosing regimen necessary to achieve cure of infection were derived. METHODS Eight healthy male subje...

BACKGROUND & AIMS All-oral regimens are associated with high cure rates in hepatitis C virus-genotype 1 (HCV-GT1) patients. Our aim was to assess the value of cure to the society for treating HCV infection. METHODS Markov model for HCV-GT1 projected long-term health outcomes, life years, and quality-adjusted life years (QALYs) gained. The model compared second-generation triple (sofosbuvir+pe...

The variation of the monomeric friction coefficient of styrene butadiene copolymer (SBR) and natural rubber (NR) with various degrees of cure was analyzed. Samples with different levels of cure were prepared. Loss tangent measurements of the samples were performed by means of a damped torsion pendulum between 173 K and 373 K. Data were analyzed in the frame of the Kloczkowsky, Mark and Frisch m...

BACKGROUND AND PURPOSE This study presents a statistical model to explore the presence of a population-based cure fraction in populations with a GBM. PATIENTS AND METHODS Data for this study was obtained from the Surveillance, Epidemiology and End-Results (SEER) database. Relative survival measures were modelled using non-mixture cure fraction models. RESULTS The extraction and subsequent p...

Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages. Due to the natural host-parasite relationship, pigs infected with A. suum make an excellent model to study the mechanisms of protection against this nematode. In pigs, a self-c...

As cancer therapy has progressed dramatically, its goal has shifted toward cure of the disease (curative therapy) rather than prolongation of time to death (life-prolonging therapy). Consequently, the proportion of cured patients (c) has become an important measure of the long-term survival benefit derived from therapy. In 1949, Boag addressed this issue by developing the parametric log-normal ...