Progastrin and insulin-like growth factors (IGFs) stimulate hyperproliferation of intestinal epithelial cells (IECs) via endocrine/paracrine routes; hyperproliferation is a known risk factor for colon carcinogenesis. In the present study, inhibitory potency of curcumin in the presence or absence of progastrin and/or IGF-II was examined. Progastrin and IGF-II significantly increased proliferatio...

BACKGROUND Recent studies report curcumin nanoformulation(s) based on polylactic-co-glycolic acid (PLGA), β-cyclodextrin, cellulose, nanogel, and dendrimers to have anticancer potential. However, no comparative data are currently available for the interaction of curcumin nanoformulations with blood proteins and erythrocytes. The objective of this study was to examine the interaction of curcumin...

Curcumin, a polyphenolic compound has several pharmacological activities, such as anticancer, anti-inflammatory and antioxidant effects. However, curcumin shows poor oral bioavailability. The purpose of this study was to investigate the protective effects of highly bioavailable curcumin, Theracurmin(®), and curcumin, against sodium nitroprusside (SNP)-induced oxidative damage in mice brain. Int...

Title of dissertation: EFFECT OF AGING ON COLONIC CHEMOPREVENTION BY DIETARY CURCUMIN Youngjoo Kwon, Doctor of Philosophy, 2006 Dissertation directed by: Assistant Professor Bernadene Magnuson Department of Nutrition and Food Science The incidence of cancer is highly dependent on age. The hypothesis of this thesis was that aging may alter the efficacy of dietary chemoprevention. This hypothesis...

background and objective: hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. this study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (stz)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. materials and methods: this study was conducted on 40 male...

OBJECTIVE Curcumin (diferuloylmethane) is a yellow-colored polyphenol with antiproliferative and proapoptotic activities to various types of cancer cells. This study explored the mechanism by which curcumin induces p53-null hepatoma cell apoptosis. RESULTS AKT, FOXO1, and FOXO3 proteins were downregulated after curcumin treatment. Conversely, PTEN was upregulated. Subcellular fractionations r...

Curcumin is the hydrophobic yellow pigment in turmeric with considerable health-promoting effects. However, its low water solubility and stability limit application. In current study, curcumin within Persian gum (PG) nanoparticles at 0.5%, 1%, 1.5% PG concentrations were encapsulated. The size of was range 326.0–397.4 nm. Based on TEM images curcumin-loaded nanoparticles, all samples had a sphe...

In presence of 7.5 microM of curcumin, no embryos or larva of zebrafish survived 3 days of incubation; however, coincubation with 144 microg/ml silymarin increased the survival rates of curcumin-treated embryos and larvae to about 70%. Moreover, in presence of 12.5 microM curcumin, all embryos died after 2 days of incubation; however, co-treatment with 144 microg/ml silymarin increased the surv...

Curcumin, the phytochemical component in turmeric, is used as a dietary spice and a topical ointment for the treatment of inflammation in India for centuries. Curcumin (diferuloylmethane) is relatively insoluble in water, but dissolves in acetone, dimethylsulphoxide, and ethanol. Commercial grade curcumin contains 10-20% curcuminoids, desmethoxycurcumin, and bisdesmethoxycurcumin and they are a...

Recently, many studies on health benefits associated with curcumin have been reported. In this study, the effects of curcumin on apoptosis of papillary thyroid cancer cell line K1 and its potential mechanisms were investigated. Curcumin was found to significantly inhibit cell viability and promoted cell apoptosis in a dose-dependent manner. Moreover, curcumin-induced cell apoptosis was characte...