In order to describe a novel approach for the clinical study of metastases, we provide here age-specific incidence and survival data for cancer of unknown primary (CUP). Metastases in various organs are found at CUP diagnosis, which have implications for prognosis, and we hypothesize similar prognostic implications for metastases found at diagnosis of primary cancers. We identified 33,224 CUP p...

We introduce here a new technique for segmenting optic cup using two-dimensional fundus images. Cup segmentation is the most challenging part of image processing of the optic nerve head due to the complexity of its structure. Using the blood vessels to segment the cup is important. Here, we report on blood vessel extraction using first a top-hat transform and Otsu's segmentation function to det...

This paper explores the enigma of cancer of unknown primary (CUP) in relation to rapidly improving molecular diagnostic approaches. It is based on the first global collaboration meeting on improving research and clinical outcomes in CUP organized by the CUP Foundation. We review the difficulties of classifying this widely heterogeneous disease and the available diagnostic and pathological evalu...

Carcinoma of unknown primary (CUP) is occasionally encountered in clinical oncology. Wide variation exists in CUP. We herein report a rare case of CUP of a mediastinal lymph node. A 61-year-old man with dermatomyositis was referred to our hospital for treatment of mediastinal adenopathy and gastric cancer. Biopsy of both lesions showed that they were histologically different from each other. Me...

BACKGROUND Acetabular cementation during total hip arthroplasty is considered difficult mainly due to the appearance and anatomy of the acetabulum. Improved cementation technique has been shown to improve the longevity of acetabular components. METHOD We designed a ceramic model to investigate the effect of varying the initial cement pressurization and cup introduction times on the depth of c...

We present a novel framework for depth based optic cup boundary extraction from a single 2D color fundus photograph per eye. Multiple depth estimates from shading, color and texture gradients in the image are correlated with Optical Coherence Tomography (OCT) based depth using a coupled sparse dictionary, trained on image-depth pairs. Finally, a Markov Random Field is formulated on the depth ma...

Transbronchial lung biopsy is a useful procedure to obtain an alveolar specimen in the evaluation of diffuse lung infiltrates. Large forceps (cup and alligator) are expected to result in larger specimens and improve diagnostic yield. We performed transbronchial lung biopsy in 20 patients using two different sized forceps in each patient. We compared the histology and histopathologic diagnoses o...

In this paper, the finite element method is employed in conjunction with the abductive network to predict the optimum blank contour of elliptic cylindrical cup with ear-less in deep drawing. The earring behavior of the formed cup is caused primarily by planar anisotropy in the sheet. Different cup heights combined with various aspect ratios of the elliptic cylindrical cup are taken into account...

In this paper, we propose a superpixel classification based optic cup segmentation for glaucoma detection. In the proposed method, each optic disc image is first over-segmented into superpixels. Then mean intensities, center surround statistics and the location features are extracted from each superpixel to classify it as cup or non-cup. The proposed method has been evaluated in one database of...

BACKGROUND Positron emission tomography (PET)-CT is a useful diagnostic adjunct for cancer unknown primary (CUP) of the head and neck; however, the increased cost has not been justified with an economic evaluation in this patient population. METHODS A decision tree analysis was performed from the perspective of the third party payer. Primary outcome was cost per life year gained ($/LYG). The ...