PURPOSE The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment-based prognostic score, based on histopathologic assessment of the tumor inflammatory cell infiltrate and tumor stroma, in patients with primary operable colorectal cancer. EXPERIMENTAL DESIGN ...

BACKGROUND The frequency of skin tumors of all types and specifically of squamous cell carcinoma (SCC) is increased in heart transplantation (HT), but the predisposing risk factors are controversial. METHODS AND RESULTS We studied 300 patients (age 49+/-15 years, 258 men, mean follow-up 4.6 years, follow-up range 1 month to 12 years) who were receiving standard double (cyclosporin plus azathi...

S U M M A R Y Motivated by a recent resurgence in earthquake predictability research, we present a method for testing alarm-based earthquake predictions. The testing method is based on the Molchan diagram—a plot of miss rate and fraction of space–time occupied by alarm—and is applicable to a wide class of predictions, including probabilistic earthquake forecasts varying in space, time, and magn...

Ideal cardiovascular health (CVH) has been defined by the American Heart Association as the absence of disease and presence of 7 key health factors. Since it is unknown whether cumulative exposure to CVH reduces the risk of developing arterial hypertension, we prospectively examined the potential association between cumulative CVH (cumCVH) score (except for blood pressure metrics) and incident ...

conclusions: using these factors, nephrologists may predict the occurrence of graft loss or death. if the probability of graft loss was higher, physicians can decrease the immunosuppressive medications dosage to decrease the incidence of graft loss. patients and methods: fine-gray model was used for 266 cases with post-transplant malignancy in iran. these patients were followed-up from the diag...

Cumulative exposure to socioeconomic disadvantage across the life course may be inversely associated with coronary heart disease (CHD); the mechanisms are not fully clear. An objective of this study was to determine whether cumulative life-course socioeconomic position (SEP) is associated with CHD incidence in a well-characterized US cohort that had directly assessed childhood and adulthood mea...

INTRODUCTION Paraquat poisoning is characterized by multi-organ failure and pulmonary fibrosis with respiratory failure, resulting in high mortality and morbidity. The objective of this study was to identify predictors of mortality in cases of paraquat poisoning. Furthermore, we sought to determine the association between these parameters. METHODS A total of 187 patients were referred for man...

introduction: stem cell biology has been the subject of much recent discussion. embryonic stem (es) cells, derived from the inner cell mass of the blastocyst stage of early mammalian embryos are expected to become a powerful tool in future regenerative medicine and developmental biology due to their capacity of self-renewal and pluripotency. in the present study, the ultrastructural development...

the use of quantum dots (qdots) as bright and photostable probes for long-term fluorescence imaging is gaining more interest. thus far, (pre)clinical use of qdots remains limited, which is primarily caused by the potential toxicity of qdots. most qdots consist of cd2+ ions, which are known to cause high levels of toxicity. therefore, the cytotoxic effects of cdse quantum dots on embryonic devel...

Objectives To examine how various combinations of cognitive impairment (overall performance and specific domains) and pre-frailty predict risks of adverse outcomes; and to determine whether cognitive frailty may be defined as the combination of cognitive impairment and the presence of pre-frailty. Design Community-based cohort study. Participants Chinese men and women (n = 3,491) aged 65+ w...