BACKGROUND Cardiac troponin levels have been reported to add value in the detection of cardiovascular complications in noncardiac surgery. A sensitive cardiac troponin I (cTnI) assay could provide more accurate prognostic information. METHODS This study prospectively enrolled 142 patients with at least one Revised Cardiac Risk Index risk factor who underwent noncardiac surgery. cTnI levels we...

ported criteria of S/LC -cTnI 6.7 or S/LC -cTnT 5.3 (1, 2 ). Taken together, 55 (15.9%) of the 345 samples were positive for autoantibodies to cardiac troponin I or T isoforms. In these positive samples, 10.9% (6 of 55) were positive for both autoantibodies. The odds of being positive for both autoantibodies increased in the presence of either species; in samples positive for autoantibodies to ...

To identify a blood test that can differentiate cardiac from skeletal muscle injury in animals, we compared tissue reactivities for various species with the use of an immunoassay for human cardiac troponin I (cTnI). Tissue reactivity varied as a function of the homology of tissue troponin with human cTnI. Cardiac reactivity in large mammals was equivalent to cTnI, 9.8 +/- 0.6 mg/g, and was 2-fo...

We have analyzed by different immunological methods the proteolytic degradation of cardiac troponin I (cTnI) in human necrotic tissue and in serum. cTnI is susceptible to proteolysis, and its degradation leads to the appearance of a wide diversity of proteolytic peptides with different stabilities. N- and C-terminal regions were rapidly cleaved by proteases, whereas the fragment located between...

The Third Universal Definition of Myocardial Infarction has indicated that “sex-dependent values may be recommended for highsensitivity troponin assays” (1 ). This statement is supported by several reference-interval studies that reported that women had lower concentrations and 99th percentile cutoffs with the high-sensitivity assays than men (2, 3 ). Despite these findings, it is unclear wheth...

Abstract Background The accuracy for early identification of non-ST-elevation myocardial infarction (NSTEMI) in the emergency department must be determined all novel high-sensitivity cardiac troponin assays (hs-cTn). In this prospective, multi-centre study we developed rule-out algorithms a I (hs-cTnI) assay and compared it to established hs-cTnT hs-cTnI. Methods Two NSTEMI were from derivation...

I have chosen to address the argument of why cardiac troponin I (cTnI) assays will likely never be standardized. It is not that I do not wish it would happen, but I think the scientific, evidence-based story I will present regarding this cardiac specific protein will speak for itself. As a means to present this argument, I would like to consider the following analogy. I am an avid trail runner....

To the Editor: I read with great interest the report by Eriksson et al. (1 ), discussing the existence of a frequently occurring blood component that interferes with immunoassays measuring cardiac troponin I (cTnI) by use of antibodies against epitopes in the central part of the molecule. As a main indicator of the assay accuracy, the authors studied the analytical recovery of a purified prepar...

Cardiac troponin I (cTnI), a specific marker of myocardial damage, is widely used in man and of increasing importance in veterinary medicine. It is not commonly used in cattle practice although it might be useful as a diagnostic aid of pericarditis. Pericarditis is a common complication of traumatic reticuloperitonitis in cattle but clinical signs are non-specific and diagnostic aids are not re...

BACKGROUND Past investigations regarding the utility of high-sensitivity cardiac troponin I (cTnI) assays have been focused primarily on the acute coronary syndrome setting. We assessed whether such assays can predict future ischemic cardiovascular events in a stable high-risk population. METHODS We quantified serum cTnI using an investigational high-sensitivity assay (hs-cTnI IUO, Beckman Co...