نتایج جستجو برای: ct26 cells
تعداد نتایج: 1383625 فیلتر نتایج به سال:
UV-inactivated, replication-defective Sendai virus particles [hemagglutinating virus of Japan envelope (HVJ-E)] injected into murine colon carcinoma (CT26) tumors growing in syngeneic BALB/c mice eradicated 60% to 80% of the tumors and obviously inhibited the growth of the remainder. Induced adaptive antitumor immune responses were dominant in the tumor eradication process because the effect wa...
Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells. In this study, we document parallel regulation of CD8(+) T cells and Foxp3(+) Tregs by programmed death-1 (PD-1, PDCD1). In addition, we identify an additional role of CTL antigen-4 (CTLA-4) inhibitory receptor in further promoting dysfunction of CD8(+) T effector cells in tumor models (CT26 colon ...
هدف: کشت سلول های اسپرماتوگونی و تولید سلول های پر توان embryonic stem cells (es like cells) که دارای قابلیت بازسازی و تولید هرسه نوع لایه زایای جنینی می باشند، این سلول ها را به عنوان منبع کافی و جدیدی برای سلول درمانی و ترمیم در بیماریها از جمله بیماریهای نورودژنراتیو پیشنهاد می دهد. در تحقیق حاضر تمایز سلول های اسپرماتوگونی موش به سلول های شبه الیگودندروسیت و نقش آنها درمیلین سازی پس از پیون...
KML001 is sodium metaarsenite, and has shown cytotoxic activity in human tumor cell lines. The anti-cancer mechanism of KML001 involves cancer cell destruction due to DNA damage at the telomeres of cancer cell chromosomes. In this study, we assessed the vascular disrupting properties of KML001 and investigated whether KML001 as VDA is able to increase anti-tumor activity in irinotecan combined ...
The PRAME tumor antigen is a potential target for immunotherapy. We assessed the immunogenicity, the antitumor activity, and the safety and the tolerability of a recombinant PRAME protein (recPRAME) combined with the AS15 immunostimulant (recPRAME+ AS15) in preclinical studies in mice and Cynomolgus monkeys. Four groups of 12 CB6F1 mice received 4 injections of phosphate-buffered saline (PBS), ...
Boron neutron capture therapy (BNCT) was performed at the University of Missouri Research Reactor in mice bearing CT26 colon carcinoma flank tumors and the results were compared with previously performed studies with mice bearing EMT6 breast cancer flank tumors. Mice were implanted with CT26 tumors subcutaneously in the caudal flank and were given two separate tail vein injections of unilamella...
Abstract Tumors evade immune surveillance by creating a hostile environment that impairs the functions of cells. Persistent perturbations including chronic antigen stimulation and metabolic challenges cause endoplasmic reticulum (ER) stress unfolded protein responses (UPR) in T CNPY2 is one key initiators UPR ER, but its roles cell activation persistence have not been reported. Herein, we found...
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