histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. so design of new inhibitors is of great importance in pharmaceutical industries and labs. creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. this approach reduces the overall cost ass...

introduction computed tomography scans are a very important tool for diagnosis and assessment of response to treatment in the practice of medicine. ionizing radiation in medical imaging is undoubtedly one of the most powerful diagnostic tools in medicine. yet, as with all medical interventions, there are potential risks in addition to the clear potential benefits. materials and methods two refe...

introduction:  the  advent  of  dual-modality  pet/ct  scanners  has  revolutionized  clinical  oncology  by  improving lesion localization and facilitating treatment planning for radiotherapy. in addition, the use of  ct images for ct-based attenuation correction (ctac) decreases the overall scanning time and creates  a noise-free  attenuation  map  (6map).  ctac  methods  include  scaling,  s...