نتایج جستجو برای: cs3 pili

تعداد نتایج: 2568  

Journal: :The Journal of rheumatology 2010
Steeve Kwan Tat Jean-Pierre Pelletier François Mineau Nicolas Duval Johanne Martel-Pelletier

OBJECTIVE During osteoarthritis (OA), the altered metabolism of cartilage involves proinflammatory factors and matrix metalloprotease (MMP) activity. Studies showed that chondroitin sulfate (CS) may exert a positive effect on the cartilage. Because of differences in CS in terms of purity and the production/purification process, we compared the effects of 3 different types of CS on human OA cart...

Journal: :Infection and immunity 2004
Paul E Orndorff Aditya Devapali Sarah Palestrant Aaron Wyse Mary Lou Everett R Randal Bollinger William Parker

The binding of human secretory immunoglobulin A (SIgA), the primary immunoglobulin in the gut, to Escherichia coli is thought to be dependent on type 1 pili. Type 1 pili are filamentous bacterial surface attachment organelles comprised principally of a single protein, the product of the fimA gene. A minor component of the pilus fiber (the product of the fimH gene, termed the adhesin) mediates a...

Journal: :The Journal of biological chemistry 1994
F Jacob-Dubuisson R Striker S J Hultgren

Assembly of P pili on the surface of pyelonephritic Escherichia coli proceeds from periplasmic chaperone-subunit complexes. The outer membrane protein PapC, which has been termed a molecular usher, is thought to be the site of assembly, where the chaperone dissociates from the subunits as they are incorporated into the pilus across the outer membrane. The kinetics of assembly and the energy req...

2005
Francisco Dionisio

Problem: Conjugative plasmids manipulate their bacterial hosts to express sex-pili – long, filamentous organelles whose genes are carried by the plasmids themselves. Sex-pili locate and attach to another bacterial cell for plasmid transfer. Bacteria differ in their ability to express sex-pili and hence to donate plasmids. Does this diversity in sex-pilus expression contribute to the survival of...

Journal: :Chembiochem : a European journal of chemical biology 2001
A Svensson A Larsson H Emtenäs M Hedenström T Fex S J Hultgren J S Pinkner F Almqvist J Kihlberg

KEYWORDS: antibiotics´bioorganic chemistry´chaperone proteins´peptidomimetics The heavy use of antibiotics during the second half of the last century has resulted in widespread bacterial resistance. Overcoming resistance requires the development of antibiotics aimed at new targets in microorganisms. Preferably, such targets should be highly conserved in bacteria and required for pathogenesis, b...

2015
Johannes Taktikos Yen Ting Lin Holger Stark Nicolas Biais Vasily Zaburdaev Stuart Humphries

Type IV pili (Tfp) are prokaryotic retractable appendages known to mediate surface attachment, motility, and subsequent clustering of cells. Tfp are the main means of motility for Neisseria gonorrhoeae, the causative agent of gonorrhea. Tfp are also involved in formation of the microcolonies, which play a crucial role in the progression of the disease. While motility of individual cells is rela...

2012
Virginie Oxaran Florence Ledue-Clier Yakhya Dieye Jean-Marie Herry Christine Péchoux Thierry Meylheuc Romain Briandet Vincent Juillard Jean-Christophe Piard

The genome of Lactococcus lactis strain IL1403 harbors a putative pilus biogenesis cluster consisting of a sortase C gene flanked by 3 LPxTG protein encoding genes (yhgD, yhgE, and yhhB), called here pil. However, pili were not detected under standard growth conditions. Over-expression of the pil operon resulted in production and display of pili on the surface of lactococci. Functional analysis...

Journal: :Journal of bacteriology 1978
W Paranchych L S Frost M Carpenter

The amino-terminal amino acid sequence of the pili protein from Pseudomonas aeruginosa K pili is presented. The sequence is compared with those reported by others for pilin obtained from Neisseria gonorrhoeae and Moraxella nonlique-faciens. All three sequences are highly homologous, contain only two hydrophilic residues in the first 22 positions, and contain an unusual amino acid, N-monomethylp...

Journal: :Current opinion in structural biology 2000
F G Sauer M Barnhart D Choudhury S D Knight G Waksman S J Hultgren

Bacterial pili assembled by the chaperone-usher pathway can mediate microbial attachment, an early step in the establishment of an infection, by binding specifically to sugars present in host tissues. Recent work has begun to reveal the structural basis both of chaperone function in the biogenesis of these pili and of bacterial attachment.

Journal: :Journal of clinical microbiology 1985
D H Francis R A Wilson

Naturally occurring dual infections with Escherichia coli of different serogroups occurred in 12 pigs 2 to 14 days of age. In each case, one isolate was hemolytic and produced K88 pili and the other was nonhemolytic and produced either K99 or 987P pili.

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