objective: diabetic neuropathy is the most common complication of diabetes mellitus affecting the nervous system. in this study, we investigated the in vivo effects of combined administration of 4-methylcatechol (4-mc) and progesterone (p) as a potential therapeutic tool for sciatic nerve function improvement and its role in histomorphological alterations in diabetic neuropathy in rats. materia...

Objective-Effect of local administration of laminin and fibronectin on nerve regeneration was assessed. Design- Experimental study. Animal- Sixty male Wistar rats. Procedures- The animals were divided into four experimental groups (n=15), randomly: In transected group left sciatic nerve was transected and stumps were fixed in adjacent muscle. In treatment group (CHIT/LF) the defect was bridg...

Abstract Introduction: neuropathy is a condition in which the peripheral nervous system is disrupted. The study of the effects of antioxidants on the performance improvement of this system is vital. This study was aimed at the investigation of the effects of date extract on nerve conduction velocity, distal latency, and wave height of the sciatic nerve in male rats. Materials and Methods: thi...

Background: Neuropathy is one of the important complications of diabetes. Deficiency of the nerve conduction velocity (NCV) that occurs in both human diabetic neuropathy and animal diabetes models is one of the indicators for diabetic neuropathy. In the present study, we examined the effect of enalapril, angiotensinconverting enzyme inhibitor on NCV, number of endoneurial capillaries and th...

The incidence of iatrogenic peripheral nerve injury during hip arthroplasty procedures has been reported to be between 0.6 and 1.3 percent. The relative risk of nerve palsy is higher in certain groups of patients such as women, patients with developmental dysplasia of the hip, and those who have undergone revision arthroplasty. In this study, the dynamic relationship between the acetabulum and ...

BACKGROUND Blockade of the sciatic nerve is necessary for complete analgesia of the lower extremity using peripheral nerve blocks. We identified the sciatic nerve in relation to the ischial tuberosity in fresh cadaver dissections as well as in patients to compare sciatic nerve blockade using the conventional approach versus our experimental approach. Specifically, we tested the hypothesis that ...

Objectives: Crocin and safranal, the major constituents of saffron, exert neuroprotective effects. In the present study, we investigated the effects of crocin and safranal  (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. Materials and Methods: Diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (STZ) and confirmed by blood glu...

Total hip arthroplasty (THA) in patients with high hip dislocation is challenging and technically demanding. Nerve injury is a problem associated with leg lengthening after THA. The purpose of this study was to identify the risk factors for sciatic nerve injury after THA in patients with high hip dislocation. Thirty-seven patients (41 THAs) with Crowe type IV hips were consecutively treated. Th...

A Cadaveric Study of Sciatic Nerve and It's Level of Bifurcation ABSTRACT Sciatic nerve, the thickest nerve in the body, formed in the pelvis, emerges through greater sciatic foramen to enter the gluteal region, then the nerve passes on the back of thigh to reach the superior angle of popliteal fossa and bifurcates into tibial and common peroneal nerves. But the level of bifurcation varies. The...

Recent work has demonstrated that apo E secretion and accumulation increase in the regenerating peripheral nerve. The fact that apoE, in conjunction with apoA-I and LDL receptors, participates in a well-established lipid transfer system raised the possibility that apoE is also involved in lipid transport in the injured nerve. In the present study of the crushed rat sciatic nerve, a combination ...