BACKGROUND Abnormal metabolism of fatty acids (FA) is considered to play a role in human cancers, including esophageal cancer (EC). Nevertheless, there have been only a few studies dealing with the influence of the chemotherapy or radiotherapy on the plasma FA profiles. In this work we compared FA in plasma phosphatidylcholine (PC) of the patients with squamous EC and healthy subjects and inves...

OVERVIEW: Intensity Modulated Radiotherapy (IMRT) is a radiation technique, which enables an even dose to be given across the breast. The aim of this large randomised trial was to investigate whether IMRT reduces toxicity to breast tissue and produces a better appearance at 5 years after treatment compared with two-dimensional breast radiotherapy (2DRT). Treatment plans of 1145 patients with ea...

Background: The present work aims to study the out-of-field photon calculation accuracy of a commercial treatment planning system (TPS), Oncentra, for three-dimensional conformal radiotherapy (3D-CRT) and intensity modulated radiation therapy (IMRT) treatment techniques from Elekta Synergy medical linear accelerator. Materials and Methods: Accuracy of individual out-of-field dose components was...

BACKGROUND The aim of this study was to compare radiotherapy plans for Stage I-II nasal natural killer/T-cell lymphoma (NNKTL) using helical tomotherapy (HT), volumetric-modulated arc therapy (VMAT), Fixed-Field intensity-modulated radiotherapy (IMRT), and three-dimensional conformal radiotherapy (3D-CRT). METHODS Eight patents with Stage I-II NNKTL treated with IMRT were re-planned for HT, V...

INTRODUCTION Pediatric high-grade gliomas are rare tumors with poor outcomes and incompletely defined management. We conducted a multi-institutional retrospective study to evaluate association of clinical, pathologic, and treatment characteristics with outcomes. MATERIALS AND METHODS Fifty-one patients treated from 1984 to 2008 at the Ohio State University or University of Michigan were inclu...

Background: Preoperative chemoradiotherapy (CRT) with 5-FU has been widely used to improve local control of disease and to preserve anal sphincter in the treatment of rectal cancer. UFT and S-1 as oral dihydropyrimidine dehydrogenase (DPD)-inhibitory fluoropyrimidines enhance the therapeutic effect of 5-FU by modulating its metabolic pathways. The purpose of this study was to evaluate the effic...

Background: To evaluate the dosimetric difference between conventional and three-dimensional conformal Radiotherapy (3D-CRT) using 6 and 18 MV X-ray photons. Materials and Methods: Computed tomography scans of 26 pelvic patients were acquired and transferred to the 3D treatment planning system. For each patient, 8 Conventional plans (3, 4, 5 and 6 Fields) and one 3D-CRT plan were prep...

PURPOSE The purpose of this study was to compare the results of postoperative adjuvant radiotherapy (RT) and concurrent chemoradiotherapy (CRT) in stage I-II endometrial carcinoma. MATERIALS AND METHODS We analyzed a total of 64 patients with surgically staged I-II endometrial carcinoma who were treated with postoperative adjuvant RT or concurrent CRT between March 1999 and July 2013. Thirty-...

BACKGROUND Despite several investigations, second malignancy risks (SMR) following radiotherapy alone (RT), chemotherapy alone (CT) and combined chemoradiotherapy (CRT) for Hodgkin's lymphoma (HL) remain controversial. PATIENTS AND METHODS We sought individual patient data from randomised trials comparing RT versus CRT, CT versus CRT, RT versus CT or involved-field (IF) versus extended-field ...

BACKGROUND The advent of IMRT and image-guided radiotherapy (IGRT) in combination with involved-field radiotherapy (IF-RT) in inoperable non-small-cell lung cancer results in a decreased incidental dose deposition in elective nodal stations. While incidental nodal irradiation is considered a relevant by-product of 3D-CRT to control microscopic disease this planning study analyzed the impact of ...