It was proposed that the experience of crowding occurs in a two-step process: First, the individual becomes aroused by violations of his personal space, and then he attributes the cause of this arousal to other people in his environment. Based on this model it was predicted that violations of personal space rather than simple density is the spatial variable associated with crowding. Further, it...

Crowding, the phenomenon of impeded object identification due to clutter, is believed to be a key limiting factor of form vision in the peripheral visual field. The present study provides a characterization of object crowding in age-related macular degeneration (AMD) measured at the participants' respective preferred retinal loci with binocular viewing. Crowding was also measured in young and a...

Macromolecular crowding is one of the key characteristics of the cellular environment and is therefore intimately coupled to the process of protein folding in vivo. While previous studies have provided invaluable insight into the effect of crowding on the stability and folding rate of protein tertiary structures, very little is known about how crowding affects protein folding dynamics at the se...

To test whether first- and second-order stimuli are processed independently in amblyopic vision, we measured thresholds for identifying a target letter flanked by two letters for all combinations of first- and second-order targets and flankers. We found that (1) the magnitude of crowding is greater for second- than for first-order letters for target and flankers of the same order type; (2) subs...

Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture. Here, we induced macromolecular crowding in vitro by using synthetic macromolecular globules of nm-scale radius at physiological levels of fractional volume occupancy. We quantified the impact of induced crowding on...

The crowding effect is a ubiquitous phenomenon in spatial perception that has been extensively investigated. A notable property of spatial crowding is the radial and tangential asymmetry in which crowding is much more severe for items arranged on a radial line originating from the fixation point compared with items arranged tangentially with regard to the fixation point. Here, we report another...

Both cellular environmental factors and chemical modifications critically affect the properties of nucleic acids. However, the structure and stability of DNA containing abasic sites under cell-mimicking molecular crowding conditions remain unclear. Here, we investigated the molecular crowding effects on the structure and stability of the G-quadruplexes including a single abasic site. Structural...

The extremely high concentration of macromolecules in a eukaryotic cell nucleus indicates that the nucleoplasm is a crowded macromolecular solution in which large objects tend to gather together due to crowding forces. It has been shown experimentally that crowding forces support the integrity of various nuclear compartments. However, little is known about their role in control of chromatin dyn...

Crowding is impairment of peripheral object identification by nearby objects. Critical spacing (the minimum target-flanker distance that does not produce crowding) scales with target eccentricity and is consistently reported as roughly equal to or less than 50% of target eccentricity (0.5e). This study demonstrates that crowding occurs far beyond the typical critical spacing when the target is ...

Study was carried out to determine the prevalence of malocclusion and its relation with crowding and spacing in orthodontically referred patients in a Karachi sample. 1082 patients were examined (362 males and 720 females) over the period of three years. Malocclusion was categorized according to Angles classification. Study model of each subject was used to assess crowding & spacing in both max...