We study a cross-dock operator’s truck scheduling problem at inbound doors in case of unknown truck arrival times. Due to uncertainty of truck arrivals, a scheduling strategy is subject to variations in costs of serving the trucks. A cost-stable scheduling strategy is defined as a schedule with low variation levels. In this paper, we analyze the cross-dock operator’s problem of determining a co...

In this work, we study the problem of determining the minimum scheduling length that can satisfy end-to-end (ETE) traffic demand in scheduling-based multihop WSNs with cooperative multiple-input multiple-output (MIMO) transmission scheme. Specifically, we present a cross-layer formulation for the joint routing, scheduling and stream control problem by incorporating various power and rate adapta...

An unusually large data set of 397 piperazinyl-glutamate-pyridines/pyrimidines as potent orally bioavailable P2Y(12) antagonists for inhibition of platelet aggregation was studied for the first time based on the combination of three-dimensional quantitative structure-activity relationship (3D-QSAR), molecular docking, and molecular dynamics (MD) methods. The comparative molecular field analysis...

BACKGROUND Cross-docking is an approach to find the best holo structures among multiple structures available for a target protein. RESULTS CrossDocker significantly decreases the time needed for setting parameters and inputs for performing multiple dockings, data collection and subsequent analysis. CONCLUSION CrossDocker was written in Python language and is available as executable binary f...

Side-chain or even backbone adjustments upon docking of different ligands to the same protein structure, a phenomenon known as induced fit, are frequently observed. Sometimes point mutations within the active site influence the ligand binding of proteins. Furthermore, for homology derived protein structures there are often ambiguities in side-chain placement and uncertainties in loop modeling w...

   In cross docking strategy, arrived products are immediately classified, sorted and organized with respect to their destination. Among all the problems related to this strategy, the vehicle routing problem (VRP) is very important and of special attention in modern technology. This paper addresses the particular type of VRP, called VRPCDTW, considering a time limitation for each customer/retai...

The Transportation Research Forum, founded in 1958, is an independent, nonprofit organization of transportation professionals who conduct, use, and benefit from research. Its purpose is to provide an impartial meeting ground for carriers, shippers, government officials, consultants, university researchers, suppliers, and others seeking exchange of information and ideas related to both passenger...

In this paper, we propose an extension of the vehicle routing problem with crossdocking that takes into account resource constraints at the cross-dock. These constraints limit the number of docks that can be used simultaneously. To solve this new problem, we adapt a recently proposed matheuristic based on large neighborhood search. In particular, we focus on the feasibility tests for insertions...

Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...

This paper presents stride scheduling, a deterministic scheduling technique that efficiently supports the same flexible resource management abstractions introduced by lottery scheduling. Compared to lottery scheduling, stride scheduling achieves significantly improved accuracy over relative throughput rates, with significantly lower response time variability. Stride scheduling implements propor...