introduction crimean-congo hemorrhagic fever (cchf) is a viral hemorrhagic fever which transmitted by tick-bites, or through contact with infected animal tissues or secretions during and immediately post-slaughter. it can be responsible for severe outbreaks in humans. case presentation we have explained five patients of a family with (cchf), which acquired the illness at one time. every five pa...

crimean-congo hemorrhagic fever is a tick-borne viral disease reported from more than 30 countries in africa, asia, south-east europe, and the middle east. the majority of human cases are workers in livestock industry, agriculture, slaughterhouses, and veterinary practice. the current mortality rate in endemic areas varies between 5 to 20 percent depending on the geographic location and medical...

background : ticks are important vectors and reservoirs of crimean congo hemorrhagic fever (cchf) virus. human beings may be infected whenever the normal life cycle of the infected ticks on non- human vertebrate hosts is interrupted by the undesirable presence of humans in the cycle. a total of 26 species of argasid and ixodid ticks have been recorded in iran; including nine hyalomma, two rhipi...

Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal tick-borne viral infection that is widely distributed worldwide. The diagnosis is frequently missed due to the non-specific initial symptoms and the differential diagnosis included many infectious and non-infectious causes. This retrospective study describes the clinical features and final diagnoses of 116 suspect CCHF cases that wer...

Crimean-Congo hemorrhagic fever (CCHF) has been reported from more than 30 countries around the world. Ribavirin is the only drug which has in vitro effect on CCHF virus. Although there is a debate on the clinical benefit of ribavirin, some experts from the endemic areas strongly recommend ribavirin in patients with CCHF based on in vitro activity and rare adverse events with shortterm use1. He...

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication ...

Innate immunity is critically dependent on the rapid production of interferon in response to intruding viruses. The intracellular pathogen recognition receptors RIG-I and MDA5 are essential for interferon induction by viral RNAs containing 5' triphosphates or double-stranded structures, respectively. Viruses with a negative-stranded RNA genome are an important group of pathogens causing emergin...

Introduction Zoonotic diseases are an important cause of human morbidity and mortality; around 75% of recently emerging human infectious diseases are zoonoses. Herein we report the first seroprevalence study to include a range of emerging or re-emerging zoonotic pathogens of economic concern (including: Bacillus anthracis, Coxiella burnetii, Francisella spp., Brucella spp., and Crimean-Congo he...