1. Two women with severe hypokalaemic alkalosis were investigated by means of muscle biopsy before and at the end of 2 and 3 weeks respectively of intense therapy with potassium chloride. 2. The muscle biopsy material was analysed for water, electrolytes, adenine nucleotides, phosphocreatine, free creatine, pyruvate, lactate, glycogen and free amino acids. The extra- and intra-cellular distribu...

Effects of feeding of either creatine or its analog beta-guanidinopropionic acid (beta-GPA) on endurance work capacity and oxygen consumption were studied in rats. Resting high-energy phosphate contents in hindlimb muscles were lower in the beta-GPA group and higher in the creatine group than in controls. The glycogen contents in resting hindlimb muscles of rats fed beta-GPA were significantly ...

We used ³¹P-magnetic resonance spectroscopy to test the hypothesis that exercise-induced muscle damage (EIMD) alters the muscle metabolic response to dynamic exercise, and that this contributes to the observed reduction in exercise tolerance following EIMD in humans. Ten healthy, physically active men performed incremental knee extensor exercise inside the bore of a whole body 1.5-T superconduc...

Magnetic resonance spectroscopy (MRS) is used to determine the quantity of metabolites, such as creatine phosphate (PCr) and adenocine triphosphate (ATP), in the living body by collecting their nuclear magnetic resonance (NMR) spectra. In the field of MRS, the frequency spectrum of metabolites is usually obtained by applying the fast Fourier transform (FFT) (Cooley & Tukey, 1965) to the NMR sig...

Abstract Background and Aims Tubulointerstitial fibrosis is the common pathological manifestation in chronic kidney disease (CKD) can indicate whether a patient will progress to failure. The metabolic consequences of developing are not well understood. This project aimed investigate changes cortex using an adenine-diet murine model progressive CKD. Method C57Bl/6J mice were treated with adenine...

One outstanding biochemical finding in progressive muscular dystrophy (P.M.D.) is excessive creatinuria. Much of the experimental work on the disease therefore has been centered on creatinecreatinine metabolism. The conclusion has now been reached that the creatinuria in this condition arises from a normal endogenous creatine production in the presence of impaired removal of creatine from the b...

While creatine has been known to man since 1835, when a French scientist reported finding this constitutent of meat, its presence in athletics as a performance enhancer is relatively new. Amid claims of increased power and strength, decreased performance time and increased muscle mass, creatine is being hailed as a true ergogenic aid. Creatinine is synthesised from the amino acids glycine, argi...

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease and stroke. However, the potential benefits of creatine for patients with convu...