A basic monomeric phospholipase A2 from the venom of the American water moccasin, Agkistrodon piscivorus piscivorus, undergoes Ca2+-dependent, autocatalytic acylation during the course of hydrolysis of both model and natural phospholipid substrates. Acylation occurs at 2 lysine residues, Lys-7 and Lys-10, in the NH2-terminal alpha-helical segment of the enzyme, and when both positions are fully...

Membranes are an important signalling platform in plants. The plasma membrane is the point where information about the external environment must be converted into intracellular signals, while endomembranes are important sites of protein trafficking, organization, compartmentalization, and intracellular signalling. This requires co-ordinating the spatial distribution of proteins, their activatio...

cellent s-donors. They readily form complexes with transition metals. Since 1990s, the use of NHCs as ligands has lead to significant advancements in the area of Pd-catalyzed carbon–carbon bond-forming reactions, Ru-catalyzed olefin metathesis, and Rh-catalyzed hydrosilylations. NHCs have also attracted significant attention as organocatalysts. Several reactions have been catalyzed by NHCs, for...

NH2-terminal glycine myristyl acylation is a cotranslational modification that affects both protein localization and function. However, several proteins that lack NH2-terminal glycine residues, including the interleukin 1 (IL-1) precursors, also contain covalently linked myristate. To date, the site(s) of acylation of these proteins has not been determined. During an evaluation of IL-1 acylatio...

the backwardness of the countryside is most important issues of developing countries. the result of this study, based on descriptive - analysis studies, shows that revive traditional arts and crafts with much charm with planning and organizing on development stimulus projects, can direct influence on the villager’s empowerment. of course, the existence of such attractions, itself, without provi...

Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression. Abnormal strongly associated with various diseases, cancer. Thus, acetyltransferases (HATs), the “writers” that catalyze acylation, are promising targets for cancer treatment. Rapid d...

Traditionally, the notion of home crafting connotes the use of alow-techo materials and techniques; but increasingly, the once-distinct worlds of crafting and computational media have become integrated, to the mutual bene®t of both cultures. In this paper, we discuss a wide range of recurring issues in the integration of crafts and computation, drawing upon a variety of related research project...

A simple and efficient method for the synthesis of 1,1-diarylalkanes via the Friedel-Crafts-type alkylation reaction of electron-rich arenes with cinnamic acid ester derivatives or chalcones is reported. Iron triflate has been found to be the best catalyst for the Friedel-Crafts-type alkylation reaction with α,β-unsaturated carbonyl compounds. This reaction afforded β,β-diaryl carbonyl compound...