CONTEXT Cortisol is released in ultradian pulses. The biological relevance of the resulting fluctuating cortisol concentration has not been explored. OBJECTIVE Determination of the biological consequences of ultradian cortisol pulsatility. DESIGN A novel flow through cell culture system was developed to deliver ultradian pulsed or continuous cortisol to cells. The effects of cortisol dynami...

BACKGROUND The aim of this study was to compare plasma cortisol concentration during anesthesia of children with congenital heart disease who received dexmedetomidine (DEX) with those who received etomidate (ETO). MATERIAL AND METHODS We recruited 99 ASA physical status II-III pediatric patients scheduled for congenital heart disease (CHD) corrective surgery and divided into them into 3 group...

The combined administration of physiological (cold pressor) and psychological (social-evaluative threat) stressors, as in the socially evaluated cold pressor test (SECPT; Schwabe et al., 2008) activates the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. Thus far, the SECPT has been administered exclusively to individual participants, which requires substanti...

OBJECTIVE To determine the influence of brief strategic family therapy (BSFT) on salivary cortisol, anger, and health-related quality of life (QoL) in adolescent boys with bullying behaviour. METHOD We selected a sample of 72 boys demonstrating bullying behaviour from the general population and treated 36 with BSFT for 12 weeks. The other 36 boys formed the control group. Primary outcome meas...

A corticosteroid-binding protein was detected in the whey of human colostrum and milk which resembles serum corticosteroid-binding globulin in certain respects: the equilibrium association constants for cortisol and progesterone binding and the apparent molecular size, as determined by Sephadex G-200 chromatography, were similar, and cortisol andd progesterone competed strongly for binding to t...

The aim of the present study was to investigate the relationships between temperament score and blood cortisol concentration, as well as energy metabolic parameters (glucose, triglyceride, non-esterified fatty acid and cholesterol) in Tsigai lambs during fattening. The temperament of lambs was assessed (scored) by a temperament score test, where the behaviour of animals was evaluated in a 5-sco...

The plasma cortisol and glucose responses to cholecystectomy were studied in 20 healthy patients. Ten patients received preoperative intercostal nerve blocks of the 6th to 12th nerves bilaterally using 0.5% bupivacaine with adrenaline 250 micrograms. The control group had the same quantity of adrenaline infiltrated into the intercostal space. Both groups had general anaesthesia with endotrachea...

Preliminary communication The aim of the present study was to investigate whether a certain time of day may be more or less catabolic or anabolic than another and therefore of greater adaptive potential after exercise. Eighteen male university students volunteered to participate in the study. Salivary specimens were collected every 60 min over a 12 h waking period and then measured with the Sal...

The mechanism of progesterone inhibition of casein gene expression was analyzed in a two-step culture model of the whole mammary organ of the mouse. Cellular accumulation of casein mRNA (mRNA,.,) was used as a measure of casein gene expression. A specific mouse casein cDNA (cDNA,.,) was used as a hybridization probe to monitor mRN&,,, in the glands. Six days of step I incubation in medium conta...

BACKGROUND Adrenal insufficiency is a complication of transsphenoidal surgery (TSS) for pituitary adenoma, and correct identification of patients requiring glucocorticoid replacement is important. Controversy exists over which early postoperative 9 AM cortisol concentration reliably predicts hypothalamic-pituitary-adrenal (HPA) axis reserve, as defined by the insulin tolerance test (ITT). MET...