To investigate disturbances in the coronary circulation and myocardial metabolism during septic shock, we examined coronary sinus blood flow and myocardial substrate extraction in 40 patients with septic shock and 13 control patients. Patients with coronary artery disease were excluded from this study. The global hemodynamic pattern of the septic patients was characterized by a lower stroke vol...

Previous studies have suggested that (1) nitroglycerin causes vasodilatation by interacting with sulfhydryl groups in vascular smooth muscle, thereby activating guanylate cyclase and increasing the intracellular concentration of cyclic GMP, and (2) N-acetylcysteine, a source of sulfhydryl groups, potentiates the peripheral vasodilatory effect of nitroglycerin. This study was performed to explor...

Methods Twenty-four healthy volunteers (12 men, 12 women) underwent MRI in a 3 Tesla scanner (Verio, Siemens, Erlangen, Germany). CPT was performed by immersing the right ankle in ice-water during 4 min. Heart rate and blood pressure were monitored throught the protocol. Coronary sinus flow was measured at rest and during CPT using a non breath-hold velocity encoded phase contrast cine MRI (TR/...

anomalies of origin, course, and distribution of coronary arteries, including single coronary artery, are well known in patients with tetralogy of fallot. however, to the best of our knowledge, there is no published case report of pentalogy of fallot with a single coronary artery. herein, we introduce a 22-year-old female patient diagnosed via echocardiography and cardiac catheterization preope...

Markers associated with coronary restenosis must be identified to develop therapeutic strategies for improving the clinical outcome. We studied whether adhesion proteins on leukocytes and platelets from coronary sinus blood were associated with restenosis after coronary intervention in patients with stable coronary artery disease. Adhesion proteins on platelets and leukocytes were measured by f...

Coronary artery anomalies (CAAs) are a diverse group of congenital disorders whose manifestations and pathophysiological mechanisms are highly variable. The subject of CAAs is undergoing profound evolutionary changes related to the definition, morphogenesis, clinical presentation, diagnostic workup, prognosis, and treatment of these anomalies. To understand the clinical impact of CAAs, the fund...