Recanalization of coronary artery chronic total occlusions is a rapidly developing domain of percutaneous coronary interventions requiring considerable operator expertise. Tackling any aorto-ostial lesion with previously implanted stent that protrudes into aorta presents anatomical and technical challenge significantly reducing procedure success rates and is an obstacle when considering antegra...

One case of brachial artery occlusion and no cases axillary occlusions have been reported in the literature. Here we describe a 50 years old female who presented for diagnostic coronary angiogram after having positive stress test developed brachial, radial thrombosis left transradial access.

This study was undertaken to determine whether coronary reactive hyperemia is coupled to myocardial metabolic activity and thus proportional to myocardial oxygen consumption or whether it is mechanically determined, resulting from direct myogenic relaxation of coronary vascular smooth muscle in response to loss of the stretch stimulus provided by arterial blood pressure. In ten unanesthetized d...

We studied the importance of collateral blood flow in the genesis of epicardial conduction delay and ventricular arrhythmias by creating a model of myocardial ischemia in which coronary collateral channels were embolized with a rapidly hardening vinyl latex. In 33 open-chest anesthetized dogs, heart rate was held constant (18O-200/min) and the proximal left anterior descending coronary artery (...

The relationships among clinical variables, coronary anatomy, and left ventricular function during the early hours of acute myocardial infarction (AMI) were evaluated from data acquired in the Western Washington Intracoronary Streptokinase Trial. All patients had symptoms and electrocardiographic changes typical of AMI. All data were obtained before treatment with streptokinase. Mean time to ca...

BACKGROUND AND OBJECTIVES Percutaneous coronary intervention for chronic total occlusion lesions is technically difficult despite equipment advances. Changes in electrocardiographic patterns, such as Q and T waves, during chronic total occlusion can provide information about procedural success and myocardial viability. In this study, we investigated clinical, electrocardiographic, and procedura...

The derangements of cardiac rhythm that result from occlusion of coronary arteries caught the attention of the earliest experimenters in the field. By the time of the studies of Porter in 1894, it was known that "fibrillar contractions" often were the end result of coronary occlusion and that irregularities of cardiac rhythm commonly preceded terminal ventricular fibrillation. Porter remarked t...

The present study evaluated combined effects of chronic coronary occlusion and exercise training on endothelial function. Gradual occlusion was produced by placement of an ameroid constrictor around the proximal left circumflex (LCX) coronary artery of female swine. Two months after placement of the ameroid, animals were restricted to their pens or exercise trained for 16 wk. Epicardial arterie...

Cardiac sympathetic afferent fibers activated during coronary occlusion exert an excitatory influence on sympathetic discharge to the heart in cats after spinal cord section. The significance of this cardiocardiac sympathetic reflex response during myocardial ischemia in animals with an intact neuraxis is unknown. We studied the responses of efferent cardiac sympathetic nerve activity (CSNA), a...