Keratoconus is a condition characterized by biomechanical instability of the cornea, presenting in a progressive, asymmetric and bilateral way. Corneal collagen cross-linking with riboflavin and UVA (CXL) is a new technique of corneal tissue strengthening that combines the use of riboflavin as a photo sensitizer and UVA irradiation. The studies showed that CXL was effective in halting the progr...

S ince the introduction of corneal collagen crosslinking (CXL), this therapeutic procedure has been developed as an option for the management of keratoconus and other corneal ectatic conditions. A number of publications have assessed the safety and clinical efficacy of the procedure in the treatment of these conditions. Such studies seem to signify that CXL is a treatment that decreases the nee...

PURPOSE To investigate the in vivo, corneal, biomechanical changes after corneal collagen cross-linking (CXL) using the Ocular Response Analyzer (ORA) in patients with keratoconus and post-laser in situ keratomileusis (LASIK) ectasia. METHODS Single-center, prospective, randomized, controlled, clinical trial. After CXL (69 eyes, 46 keratoconus and 23 post-LASIK), corneal hysteresis (CH) and c...

Cross-linking of corneal collagen (CXL) is a promising approach for the treatment of keratoconus and secondary ectasia. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subjected to epithelial debridement and the application of a soft contact lens. Formation of tempo...

PURPOSE To report the recurrence of keratoconus 49 months after deep anterior lamellar keratoplasty (DALK). CASE REPORT A 21-year-old man with history of bilateral keratoconus who had undergone DALK in his right eye, presented with gradual visual loss 49 months after corneal transplantation. Slit lamp biomicroscopy revealed graft ectasia together with Vogt's striae in the posterior stroma and...

Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic an...

PURPOSE To compare parameters of biomechanical response of the human cornea measured as corneal hysteresis (CH) and corneal resistance factor (CRF) in patients with diabetes mellitus and healthy control subjects. SETTING Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel. METHODS In the right eye of each participant, the CH, CRF, Goldmann-correlated intraocular press...

PURPOSE To determine the efficacy of the KeraSoft(®) IC (KIC) (Ultravision International Limited, Bedfordshire, UK), a silicone hydrogel contact lens, for the optical management of non-surgical corneal ectasias and to compare it with the Rose-K 2 RGP contact lens. METHODS In a retrospective study ninety-four eyes fitted with KIC (group A) were compared with seventy-seven eyes fitted with Rose...

INTRODUCTION Keratoconus is a noninflammatory cone-like ectasia of the cornea that can be managed by glasses, contact lenses, keratoplasty, crosslin king (CXL), and intrastromal corneal ring segment (ICRS) insertion, based on the stage of the disease and the patient’s symptoms. Despite being an evolutive disease, CXL has recently been utilized as a therapeutic option for stabilizing the cornea....

importance in both screening for refractive surgery and the early treatment of keratoconus. Topography or tomography analysis using either videokeratography or optical coherence tomography instruments can help detect alteration in the shape of the cornea such as thinning and increased curvature. However, these instruments cannot measure the mechanical stability, which is thought to be the initi...