Background: In vitro maturation (IVM) of immature oocyte is a promising treatment option for infertile women.IVM procedures attempt to mimic the natural conditions of the follicular environment. The technique of IVM of oocytes has been successful after the first trial using culture of human oocytes in follicular fluid. The crucial part of this technique is the maturation process itself, and the...

OBJECTIVE To evaluate the integrity of genomic imprinting in oocytes vitrified at the germinal vesicle (GV) stage and in vitro matured (IVM) after thawing. DESIGN Clinical research and application. SETTING University-based fertility center. PATIENT(S) Immature oocytes were donated for research by patients who were included in an intracytoplasmic sperm injection program. INTERVENTION(S) ...

A field program to control multiple anthelmintic resistant worm infections in cattle of Argentina is described. In 2003 around 140 calves died as a consequence of high worm burdens despite the administration of monthly alternate treatments with ivermectin (IVM) or fenbendazole (FBZ). A fecal egg count reduction test (FECRT) showed a clinical efficacy of 73%, 49.1% and 90.4% for IVM, FBZ and lev...

This study evaluated the comparative plasma dispositions of ivermectin (IVM), doramectin (DRM) and moxidectin (MXD) following subcutaneous administration in rabbits. Fifteen New Zealand white rabbits were allocated into three groups of five animals each. The animals in each group received IVM, DRM or MXD by subcutaneous injection at a single dose of 0.3 mg/kg. Blood samples were collected at va...

Malaria continues to be a public health problem in Bangladesh, despite efforts in the 1960s to eradicate the vectors through the use of DDT. At one point, eradication of malaria was acclaimed but later on it reappeared. The use of DDT is no more legally allowed in Bangladesh, which has been officially replaced by a number organophosphates and/or synthetic pyrethroids and their combinations in a...

AimsTo evaluate whether melatonin (MT) supplementation during in vitro maturation (IVM) of human oocytes can reverse the age-related decline oocyte quality.Main methodsWe enrolled 172 patients aged ≥35 years (older reproductive-aged women) and 83 <35 (young who underwent fertilization between 2019 2022. We conducted IVM with without 10 μM MT immature different ages. Oocyte embryo development we...

150 words) Study Objective To compare intranasal fentanyl (INF) with intravenous morphine (IVM) for prehospital analgesia. Methods Randomized, controlled, open-label trial. Consecutive adult patients (n=258) requiring analgesia (Verbal Rating Score (VRS) >2/10 non-cardiac or >5/10 cardiac) were recruited. Patients received INF 180mcg +/2 doses of 60 mcg at ≥ 5 minute intervals, or IVM 2.5-5mg +...

introduction: superovulation produces complications in some patients, so invitro maturation of oocytes is used to decrease or eliminate these complications and improve ivf. moreover, ivm is used for different aspects of reproductive researches. slaughterhouse ovaries are the main source of oocytes for ivm and ivf studies. different media has been introduced and experimented for in vitro maturat...

Individual mutations (e.g. L256F) and polymorphisms in the avr-14B gene, a glutamate-gated chloride channel subunit, have been associated with ivermectin (IVM) resistance in Caenorhabditis elegans and Cooperia oncophora. The aim of the present study was to determine the full-length coding sequence of the avr-14B subunit homologue in Teladorsagia circumcincta and determine the presence/absence o...

The cortical reaction induces changes at the egg's Zona pellucida (ZP), perivitelline space and/or oolemma level, blocking polyspermic fertilization. We studied the timing of sperm penetration and cortical reaction in pig oocytes matured under different conditions and inseminated with different boars. Immature (germinal vesicle stage) and in vitro matured (IVM) (metaphase II stage) oocytes were...