BACKGROUND The present pilot study investigating the minimum dose for short-course single and double-dose treatment of kala-azar with an apparently new liposomal formulation of amphotericin B, Fungisome, led to identification of immunological components for early detection of success and/or failure to cure. METHODS Patients were treated with 5, 7.5 (single-dose) and 10 mg/kg body weight (5 mg...

The aim of this article is to present an investigation of cure rate, after long follow up, of specific chemotherapy with benznidazole in patients with both acute and chronic Chagas disease, applying quantitative conventional serological tests as the base of the criterion of cure. Twenty one patients with the acute form and 113 with one or other of the various chronic clinical forms of the disea...

Ablation is the destruction of cardiac tissue to cure rhythm disturbances and of liver tissue to cure cancer. This work presents methods, numerical results, experimental results, and applications of finite element (FE) analysis for the study of radiofrequency (RF) cardiac and hepatic ablation. I outline a process for FE modeling implementations of temperature-controlled and power-controlled RF ...

BACKGROUND Contemporary surgical treatment of female stress urinary incontinence (SUI) includes retropubic and transobturator (TO) midurethral slings (MUS). Case series of single-incision slings (SIS) have shown similar outcomes with lower morbidity. OBJECTIVE Our aim was to assess the cure rates, complications, and quality-of-life impact of one standard TO MUS and two SIS. DESIGN, SETTING,...