Abstract A 78 years old woman presented in our cardio–oncology out–patient clinic to renew apixaban treatment plan. In her medical history she was a former smoker, with chronic kidney disease IIIb stadium according KDIGOI guidelines creatinine of 1,54 mg/dl, GFR CKD 32 ml/min/1.73m2 and Cockcroft e Gault 28 ml/min/1.73m2. 2010, had right lobe pulmonary cancer diagnosis treated neo–adjuvant gemc...

The paper presents a new fast computation scheme for linear separation in two-dimensional feature space. This scheme is based on a combination of several image processing techniques: fast Hough transform, cumulative sum computation and expression of optimized criterion as a function of additive statistics. It is shown that complexity of the scheme is O(n log n) for chosen set of criteria. Two a...

We present some optimal criteria to evaluate model-robustness of non-regular two-level fractional factorial designs. Our method is based on minimizing the sum of squares of all the off-diagonal elements in the information matrix, and considering expectation under appropriate distribution functions for unknown contamination of the interaction effects. By considering uniform distributions on symm...