Aim: To identify the role of consanguinity in the appearance of deafness in children of consanguineously married couples. Materials & methods: This retrospective, record based, survey type study was carried out during April-July, 2007. We completed a questionnaire for each student after interviewing the student and the parent or guardian. We also consulted the record at the school. The data was...

~eneral terms. It might even be said that this aspect of research is frequently neglected. Blood-group experts are undoubtedly most directly responsible for this regrettable situation. Since one applies Fisher's formulas on the assumption that the blood groups are independent of age and sex, there is a tendency to confine research to any random sample of the population, which is only rarely rep...

background: neural tube defects (ntd) are one of the leading causes of infant mortality worldwide. this study was de­signed to determine the prevalence of ntds among native fars ethnic groups during 1998-2005, and to identify maternal and demographic factors associated with ntds. methods: we performed a descriptive cross-sectional hospital-based study in dezyani hospital, gorgan, north of iran,...

I must admit that when I first volunteered to review Consanguinity in Context, I had confused consanguinity with ex-san-guinity. Expecting a book about porphyria, rabies, and other possible sources of vam-pire myths, I was quite surprised to instead start reading about inbreeding. However, far from being disappointed, I found Alan Bit-tles' book to be extremely fascinating. Bit-tles provides an...

AIM To determine the association between consanguineous marriages, obesity, and environmental risk factors associated with type 2 diabetes, in the adult Qatari population. METHODS The case-control study was carried out among diabetic patients and healthy subjects at the Primary Healthcare Clinics (PHCs) and the survey was conducted from February to November 2003. The study included 338 cases ...

Women harboring pathogenic germline mutations in the BRCA1 and BRCA2 genes have high lifetime risks of developing breast and ovarian cancer (1). Therefore, it is clinically relevant to identify individuals harboring BRCA1/2 mutations to optimize cancer risk management (2). Initially the genetic risk is assessed based on a comprehensive personal and family history of cancer. Genetic testing is t...

Consanguineous marriage that defines as a union between biologically related persons has a variety of known deleterious correlations with factors that affect public health within human populations. To investigate the association between the mean of inbreeding coefficient (α) and incidence of leukemia, the present ecological study on 68 countries was carried out. Statistical analysis showed that...

In a diploid, outbreeding organism like man the deleterious mutants carried by the population are only partly expressed in each generation, being largely concealed by heterozygosis with more favorable alleles. However, the total hidden-mutational damage carried by the population can be estimated indirectly from the detrimental effects of consanguineous marriage. This method, applied to mortalit...

I must admit that when I first volunteered to review Consanguinity in Context, I had confused consanguinity with ex-san-guinity. Expecting a book about porphyria, rabies, and other possible sources of vam-pire myths, I was quite surprised to instead start reading about inbreeding. However, far from being disappointed, I found Alan Bit-tles' book to be extremely fascinating. Bit-tles provides an...