It has been assumed that cleavage of the N-terminal propeptide domain of membrane type-1 matrix metalloproteinase (MT1-MMP) is required for enzyme function. We recently demonstrated that the propeptide domain of MT1-MMP is not cleaved and actually is required for function of the membrane-bound enzyme in transfected COS-1 cells (Cao, J., Drews, M., Lee, H. M., Conner, C., Bahou, W. F., and Zucke...

In the last decade, one of the most avidly studied compounds in the central nervous system (CNS) has been the neurotrophin BDNF. Although historically it had been studied in the context of development, where it plays numerous critical roles, more recent studies have shown striking actions on a number of pathways and processes that are critical for normal function of the adult CNS. In addition, ...

OBJECTIVE To determine the prevalence of behaviour disorders in low birthweight infants. DESIGN Children of birth weight < or = 2000 g born to mothers resident in Merseyside in 1980-1 assessed using the Rutter parent and teacher behaviour questionnaires and the Conner modification of the Rutter teacher questionnaire. Children attending normal schools were assessed with controls matched for ag...

Suicidal behavior and alcohol use are major public health concerns in the United States; however the association between these behaviors has received relatively little empirical attention. The relative lack of research in this area may be due in part to the absence of theory explaining the alcohol use-suicidality link in the general adult population. The present article expands upon Conner, McC...

Objective Previous studies have reported that childhood maltreatment experiences could induce biological and psychological vulnerability in depressive disorders. However, it is still unclear that type-specific effects of childhood maltreatment on psychological resilience, depressive symptoms and interactions among childhood maltreatment experiences, resilience, and depressive symptoms. Method...

Transverse sternal nonunion, repair and revision: a case report and review of the literature. J Trauma. 2009;66:1485–8. 3. Potaris K, Gakidis J, Mihos P, Voutsinas V, Deligeorgis A, Petsinis V. Management of sternal fractures: 239 cases. Asian Cardiovasc Thorac Ann. 2002;10:145–9. 4. Morgan A. Treatment of chronic nonunion of a sternal fracture with bone morphogenetic protein. Ann Thorac Surg. ...

The techniques of crystallization, developed in recent years, have permitted enzyme studies that are far more exact than were possible with the more crude preparations. Among the crystalline enzymes, Northrop’s pepsin has been the object of widespread and intensive research (1) which has contributed to the knowledge of enzyme action and mode of operation. In order to further the understanding o...

The European Society of Cardiology has a comparable organization in the U.S.A. in the American Heart Association, whose first president was Dr Lewis Atterbury Conner. Dr Connor was also the founding editor of the American Heart Journal. His contributions in the early 20th century were as significant as those of any single individual in focusing concerns about the emerging importance of cardiova...

Although pettiness, defined as the tendency to get agitated over trivial matters, is a facet of neuroticism which has negative health implications, no measure exists. The goal of the current study was to develop, and validate a short pettiness scale. In Study 1 (N = 2136), Exploratory Factor Analysis distilled a one-factor model with five items. Convergent validity was established using the Big...

Point mutations in cardiac myosin, the heart's molecular motor, produce distinct clinical phenotypes: hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Do mutations alter myosin's molecular mechanics in a manner that is predictive of the clinical outcome? We have directly characterized the maximal force-generating capacity (F(max)) of two HCM (R403Q, R453C) and two DCM (S532P, F764L) mutant ...