• Direct surgical manipulation of the developing embryo heart is one of several physical and chemical methods that are known to produce congenital cardiac anomalies in experimental animals.' This procedure involves the concept that the pattern of blood flow through the embryonic heart is of prime importance in cardiogenesis. It is thought that the primitive cardiac tube is molded by the streami...

We used whole exome sequence analysis to investigate a possible genetic etiology for a patient with the phenotype of intrauterine growth restriction, microcephaly, developmental delay, failure to thrive, congenital bilateral hip dysplasia, cerebral and cerebellar atrophy, hydrocephalus, and congenital diaphragmatic hernia (CDH). Whole exome sequencing identified a novel de novo c.2722G > T (p.E...

The precise mechanisms for SIDS, or “crib death,” are not known, although multiple hypotheses have been proposed over the years, including abnormal brainstem respiratory control of arousal, dysautonomia, and malignant cardiac bradyarrhythmias or tachyarrhythmias.2–4 Genetic, developmental, and environmental risk factors for SIDS have been identified, such as premature birth, multiple gestations...

The precise mechanisms for SIDS, or “crib death,” are not known, although multiple hypotheses have been proposed over the years, including abnormal brainstem respiratory control of arousal, dysautonomia, and malignant cardiac bradyarrhythmias or tachyarrhythmias.2–4 Genetic, developmental, and environmental risk factors for SIDS have been identified, such as premature birth, multiple gestations...

Holt-Oram syndrome is an autosomal dominant disorder, characterised by skeletal abnormalities of the upper limb associated with congenital heart defect, mainly atrial and ventricular septal defects. Skeletal defects exclusively affect the upper limbs in the preaxial radial ray distribution and are bilateral and asymmetrical. They range from clinodactyly, absent or digitalised thumb, hypoplastic...

Abstract Background Congenital heart disease (CHD) is the most common neonatal anomaly. Extracardiac findings are commonly associated with CHD. It mandatory to evaluate extracardiac structures for potential abnormalities that might impact surgical planning these patients. The purpose of this study was determine could associate cardiac anomalies and give insights into their embryological aberrat...

BACKGROUND  Congenital left ventricular aneurysm (LVA) and diverticulum (LVD) are rare cardiac anomalies frequently associated with electrocardiogram (ECG) abnormalities. The aim of this study was to evaluate the long-term prognosis in such patients. METHODS AND RESULTS  A total of 108 patients with LVA or LVD having ECG-abnormalities were assessed. The patients were classified into 2 groups ...