نتایج جستجو برای: conditioned medium

تعداد نتایج: 259755  

Journal: :Journal of immunology 2001
T Yamane T Kunisada H Tsukamoto H Yamazaki H Niwa S Takada S I Hayashi

Hemopoietic cells develop in a complex milieu that is made up of diverse components, including stromal cells. Wnt genes, which are known to regulate the fate of the cells in a variety of tissues, are expressed in hemopoietic organs. However, their roles in hemopoiesis are not well characterized. In this study, we examined the roles of Wnt proteins in hemopoiesis using conditioned medium contain...

Journal: :Cancer research 1985
E Niskanen R Rahman

Medium conditioned in the presence of human HUT-102 T-cell line cells contains activities stimulating human mixed (colony-forming unit, erythroid, granulocyte, macrophage, megakaryocyte) and erythroid (burst-forming unit, erythroid) colony formation in methylcellulose in vitro and granulocyte colony formation in diffusion chambers in mice. The stimulatory effect of HUT-102-conditioned medium on...

Journal: :Stroke 2013
Mari Yamagata Akihito Yamamoto Eisuke Kako Naoko Kaneko Kohki Matsubara Kiyoshi Sakai Kazunobu Sawamoto Minoru Ueda

BACKGROUND AND PURPOSE Perinatal hypoxia-ischemia (HI) has high rates of neurological deficits and mortality. So far, no effective treatment for HI brain injury has been developed. In this study, we investigated the therapeutic effects of stem cells from human exfoliated deciduous teeth (SHED) for the treatment of neonatal HI brain injury. METHODS Unilateral HI was induced in postnatal day 5 ...

2010
Hongqi Xin Yi Li Li Hong Shen Xianshuang Liu Xinli Wang Jing Zhang Siamak Pourabdollah-Nejad D Chunling Zhang Li Zhang Hao Jiang Zheng Gang Zhang Michael Chopp

We demonstrate that tissue plasminogen activator (tPA) and its inhibitors contribute to neurite outgrowth in the central nervous system (CNS) after treatment of stroke with multipotent mesenchymal stromal cells (MSCs). In vivo, administration of MSCs to mice subjected to middle cerebral artery occlusion (MCAo) significantly increased activation of tPA and downregulated PAI-1 levels in the ische...

Journal: :Blood 1987
Y Takaue C L Reading A J Roome K A Dicke S Tindle M Chandran B Devaraj

The effects of colony-stimulating factors (CSFs), phytohemagglutinin (PHA), and hydrocortisone on the growth of human bone marrow hematopoietic progenitor cells (granulocyte-macrophage; GM) were analyzed in a limiting-dilution assay (LDA). Both low-density bone marrow cells separated by discontinuous Percoll gradients and a T cell-depleted and progenitor-enriched cell fraction obtained by the c...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1985
I Selak S D Skaper S Varon

Conditioned media from glial cell cultures contain low molecular weight agents which can support survival of CNS neurons in the absence of recognized protein neuronotrophic factors. A similar support is provided to CNS neurons by selected basal media, and pyruvate is the critical medium constituent responsible for their trophic competence. Eagle's basal medium, which contains no pyruvate, acqui...

Journal: :Circulation research 1991
A G Villanueva H W Farber S Rounds R H Goldstein

We investigated the effect of medium conditioned by bovine aortic endothelial cells on collagen accumulation and total protein formation by human embryonic fibroblasts or bovine smooth muscle cells in cultures. The conditioned medium at a 1:10 dilution induced a twofold increase in collagen and total protein accumulation in fibroblast cultures. At low concentration (1:50 dilution), the conditio...

Journal: :Molecular pharmacology 2008
Wei-Lan Yeh Chun-Jung Lin Wen-Mei Fu

Increased need for glycolysis and glucose uptake for ATP production is observed in tumor cells, particularly in cells lacking of oxygen supply. Because glucose is transported from blood to tumor, glucose molecules must be delivered across glucose transporters of the vascular endothelium and tumor cells. Here we found that glioma suffered from hypoxic insults can secrete factor(s) to regulate gl...

Journal: :Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 2013
Kyu Young Seo Dong Hyun Kim Sang Eun Lee Moon Soo Yoon Hee Jung Lee

BACKGROUND AND OBJECTIVES For skin rejuvenation, microneedle fractional radiofrequency (RF) is a recently developed minimally invasive method for delivering RF energy directly into the skin using microneedle. Additionally, the use of growth factors in skin rejuvenation is emerging as a novel anti-aging treatment. We evaluated efficacy and safety of microneedle fractional RF for skin rejuvenatio...

2017
Wei-Wei Li Hai-Yue Wang Xi Nie Ya-Bin Liu Mei Han Bing-Hui Li

Tumor vessels often lack the smooth muscle layer, and the instability is conducive to tumor invasion and metastasis. The effect of tumor microenvironment on vascular smooth muscle cells needs to be explored. In the present study, we examined the density of the tumor vessels in human colorectal cancer tissues, and used the tumor conditioned medium of human colorectal cancer HT29 cells to mimic t...

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