نتایج جستجو برای: concurrent chemotherapy
تعداد نتایج: 173103 فیلتر نتایج به سال:
Here we review the current treatments for small-cell lung cancer. Cisplatin and etoposide, combined with concurrent or alternating thoracic irradiation, have been considered to be the standard therapy for patients with limited disease. Dose-intensive weekly chemotherapy and high-dose chemotherapy with autologous stem cell transplantation have failed to increase survival in patients with extensi...
We present a rare finding of concurrent right testis non-seminomatous mixed germ cell tumor and muscle invasive urothelial carcinoma of the bladder in a 57-year-old homeless man. The socioeconomic factors and the disease presentation caused a treatment dilemma in terms of the appropriate type of neoadjuvant chemotherapy. The patient ultimately underwent upfront surgery with retroperitoneal lymp...
Abbreviations: NPC: Nasopharyngeal Carcinoma; NACT: Neoadjuvant Chemotherapy; 5y-OS: 5-Year Overall Survival; 5y-DFS: 5-Year Disease-Free Survival; 5y-RFS: 5-Year Local-RecurrenceFree Survival; 5y-MFS: 5-Year Distant-Metastasis-Free Survival; IMRT: Intensity-Modulated Radiation Therapy; CCT: Concurrent Chemotherapy; HN-MRI: Magnetic Resonance Imaging of Head and Neck; G3/4: Grade 3 To 4; CTCAE ...
Purpose: Gastrointestinal cancers frequently exhibit mutational activation of the Ras/MAPK pathway, which is implicated in resistance to ionizing radiation (IR) and chemotherapy. Concurrent radiotherapy and 5-fluorouracil (5-FU) based chemotherapy is commonly used for treatment of gastrointestinal malignancies. We previously reported radiosensitization with selumetinib, an inhibitor of MEK1/2. ...
AIMS AND BACKGROUND Small cell lung cancer is characterized by an aggressive clinical course and a high sensitivity to both chemotherapy and radiotherapy. We present the Florence University experience in concurrent early radio-chemotherapy in patients affected by limited-stage small cell lung cancer, with particular emphasis on treatment safety, disease outcome and prognostic factors. METHODS...
This paper describes the mechanisms of action of ionizing radiations combined with antineoplastic drugs. Some relevant drugs for the combined modality treatments of locally advanced lung cancer are reported. The meta-analyses including randomized trials comparing single agent (radiotherapy or chemotherapy) versus combined chemotherapy and radiotherapy in patients with unresectable non small cel...
Patients with locally advanced cervical cancer comprise a significant proportion of the total population with cervical cancer, particularly in developing countries. The inability to control pelvic tumors is still a significant concern. Although neoadjuvant chemotherapy is associated with a high response rate, data from randomized trials clearly do not support the use of neoadjuvant chemotherapy...
BACKGROUND The gold standard endpoint in clinical trials of chemotherapy and radiotherapy for lung cancer is overall survival. Although reliable and simple to measure, this endpoint takes years to observe. Surrogate endpoints that would enable earlier assessments of treatment effects would be useful. We assessed the correlations between potential surrogate endpoints and overall survival at indi...
background: inherent toxicity of cytotoxic drugs is the basis for their potential adverse risks from occupational exposure to the nursing staff. in iran, chemotherapy regimens are prescribed and administered according to the world updated protocols. but little is done regarding the protective standards in this field. methods: an observational cross-sectional survey was conducted among nurses wh...
Nagaland has the highest AAR (age adjusted rates) of Nasopharyngeal carcinoma (NPC) in India. The frequent presentation metastatic neck nodes nasopharyngeal can lead to diagnostic errors if preliminary investigations are not done properly. We present two patients with NPC who were initially treated anti-tubercular therapy presumed have tuberculosis. Metastasis was confirmed fine needle aspirati...
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