BACKGROUND Treatment of arterial hypertension in patients with severe mental illnesses often results in polypharmacy, potentially leading to drug-drug interactions. The objective of the study was to analyse the in vivo inhibitory potential of two antihypertensive drugs, amlodipine and metoprolol on CYP2D6 catalysed 9-hydroxylation of risperidone (RIS). METHODS A therapeutic drug monitoring da...

BACKGROUND AND OBJECTIVES N-Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450 (CYP) 2D6 to yield endoxifen. Because of its high antiestrogenic potency, endoxifen may play an important role in the clinical activity of tamoxifen. We conducted a prospective trial in 158 patients with breast cancer who were taking tamoxifen to further understand t...

Concurrent norfloxacin concentrations in serum, kidney, and prostatic tissue were determined in 14 patients. Mean ratios of norfloxacin concentration in tissue over concentration in serum were 6.6 +/- 2.8 for the kidney and 1.7 +/- 0.2 for the prostate samples. The levels were above the MICs of most urinary pathogens.

A new method was developed for rapid and precise simultaneous determination of Mg/Ca, Sr/Ca, Mn/Ca, Cd/Ca, Ba/Ca and U/Ca ratios in foraminiferal shells using sector field inductively coupled plasma mass spectrometry (ICPMS). Element/calcium ratios were determined directly from intensity ratios using external, matrix-matched standard to correct for instrumental mass discrimination. Because of l...

this research was conducted on polluted soil near the lead and zinc factory in zanjan province through which the effects of two organic and three mineral sources were examined on heavy metals fixation in randomized experiment design. experimental treatments includes bagasse and rice husk in three levels: 1.25, 2.5 and 5%, zeolite in three levels: 5%, 10% and 15%, phosphate rock in three rates: ...

The watermelon [Citrullus lanatus (Thunb.) Matsum. and Nakai] cultivar Crimson Tide and 7 different gourd genotypes [Cucurbita maxima, C. moschata, Luffa cylindrica, Benincasa hispida, Lagenaria siceraria landraces (Skp and Birecik), and L. siceraria hybrid (FRGold)] with rootstock potential for watermelon were grown under saline conditions (0, 4, 8, 12, and 16 dS m) to investigate the response...

Abstract. Sedimentary 231Pa/230Th ratios provide clues to estimate the strength of past ocean circulation. For its estimation, understanding processes controlling distributions 231Pa and 230Th in is important. However, simulations dissolved particulate modern ocean, recently obtained from GEOTRACES project, remain challenging. Here we report a model simulation global with COCO ver4.0. Starting ...

[1] Step-pool units, common features in steep, narrow streams, are highly dynamic systems that adjust during high flows and active sediment transport conditions. Consecutive step pools in a reach form a step-pool sequence, and though these features are prevalent in nature, quantifying the stability of such systems is challenging. This study focuses on the statistical relationships between 445 s...

1. It has been found that the ratios of the total concentrations of Ca, Mg, K, Zn, inside and outside of gelatin particles do not agree with the ratios calculated according to Donnan's theory from the hydrogen ion activity ratios. 2. E.M.F. measurements of Zn and Cl electrode potentials in such a system show, however, that the ion activity ratios are correct, so that the discrepancy must be due...

Abstract. Sedimentary 231Pa/230Th ratios provide clues to estimate the strength of past ocean circulation. For its estimation, understanding processes controlling distributions 231Pa and 230Th in is important. However, simulations dissolved particulate modern ocean, recently obtained from GEOTRACES project, remain challenging. Here we report a model simulation global with COCO ver4.0. Starting ...