PURPOSE The anticonvulsants phenytoin (PHT), carbamazepine (CBZ), and gabapentin (GBP) are commonly used in the treatment of temporal lobe epilepsy. Ca2+ current modulation has been proposed to contribute to the antiepileptic activity of these drugs. The purpose of this study was to determine the effects of these anticonvulsants on voltage-dependent calcium channels in pathologically altered ne...

introduction: the nucleus paragigantocellularis lateralis (lpgi) is involved in the descending pain modulation. the neurostreoid, 17β-estradiol found in the pgi nucleus and modulates nociception by binding to estrogen receptors and also by allosteric interaction with nmda receptors. in this study, the role of nmda receptors in the 17β-estradiol-induced pain modulation was investigated by assess...

BACKGROUND The purpose of this study is to investigate 1) whether equol has the direct modulation on vascular tone of endothelium-denuded human uterine artery, and 2) if present, whether this equol-induced modulation of vascular tone is mediated by intracellular calcium modulation through Ca(2+) & K(+) channels on vascular smooth muscle cell membrane. METHODS The uterine arteries were obtaine...

The time series of seismic noise, geomagnetic variationsandradon activity concentration in the atmosphericboundary layer were studied. data obtained by geophysical systems providing monitoring measurements inthe Republic Karelia, Russia. power spectrawere calculated and analyzed for recorded under low activity. similarity detected periods spectra with Earth’s natural oscillations is regarded as...

The synthesis of an optical three-beam ozone sensor model for the Matlab Simulink simulation is performed. structure signal processing system proposed. measuring noise resistance carried out on basis developed visual block model. dependence measurement error modulation frequency radiation in channel obtained. operation modes are determined to minimize error. It shown that precision determining ...

We describe a highly sensitive and stable quantum-cascade-laser-based attenuated total reflection (ATR) terahertz sensor for the detection of very low concentration solutions, using dual-modulation differential approach ATR geometry. This offers high dynamic range long-term stability 40 dB, which extends potential radiation analysis liquid biological samples. The performance is illustrated by m...