An operational perspective is used to understand the relationship between source and channel coding. This is based on a direct reduction of one problem to another that uses random coding (and hence common randomness) but unlike all prior work, does not involve any functional computations, in particular, no mutual-information computations. This result is then used to prove a universal source-cha...

This is a three part paper. Optimality of source-channel separation for communication with a fidelity criterion when the channel is compound as defined in [1] and general as defined in [2] is proved in Part I. It is assumed that random codes are permitted. The word “universal” in the title of this paper refers to the fact that the channel model is compound. The proof uses a layered black-box or...

An operational perspective is used to understand the relationship between source and channel coding. This is based on a direct reduction of one problem to another that uses random coding (hence common randomness) but unlike all prior work, does not involve any functional computations, in particular, no mutual-information computations. This is then used to prove a universal source-channel separa...

A multi-channel algebraic scattering theory, to find solutions of coupled-channel scattering problems with interactions determined by collective models, has been structured to ensure that the Pauli principle is not violated. Positive (scattering) and negative (sub-threshold) solutions can be found to predict both the compound nucleus sub-threshold spectrum and all resonances due to coupled chan...

Definition 1 The compound channel is a channel with a state, where the state is constant over a whole transmission block. Definition 2 A (2, n) code for a compound channel consists of the following: 1) An index set M = {1, 2, . . .2}. 2) An encoding function f : M 7−→ X. 3) A decoding function g : Y 7−→ M. Definition 3 The average probability of error P (n) e , is the probability P (n) e , Pr{M̂...

Administration of certain fluoroquinolone antibacterials has been associated with prolongation of the QT interval on the electrocardiogram and, on rare occasions, ventricular arrhythmia. Blockade of the human cardiac K+ channel HERG often underlies such clinical findings. Therefore, we examined a series of seven fluoroquinolones for their ability to interact with this channel. Using patch-clamp...

We study the identification capacity of classical-quantum channels (“cq-channels”), under channel uncertainty and privacy constraints. To be precise, we consider first compound memoryless cq-channels and determine their identification capacity; then we add an eavesdropper, considering compound memoryless wiretap cqq-channels, and determine their secret identification capacity. In the first case...

The authors used the PatchXpress 7000A system to measure compound activity at the hERG channel using procedures that mimicked the "gold-standard" conventional whole-cell patch clamp. A set of 70 compounds, including hERG antagonists with potencies spanning 3 orders of magnitude, were tested on hERG302-HEK cells using protocols aimed at either identifying compound activity at a single concentrat...