The therapeutic-equivalence. The large sample case. Abstract: Several approaches are given in the literature for therapeutic equivalence (the two one-sided test approach, the power approach, the conndence and Westlake intervals approaches, the UMP test approach) yielding distinct deenitions. This paper is aimed at passing beyond this heterogeneity in order to propose a standard deenition of the...

of pain-killing drugs. In the 1870s, the debate was primarily philosophical rather than medical. Nevertheless, the discussion drew on technological advances such as chloroform; ideas about a person's comparative worth; the fashion for social Darwinism; and palliative care. Similarly in the early 1900s, Kemp links proposals for euthanasia to the contemporary vogue for eugenics-though he is alway...

We consider optimal load balancing in a distributed computing environment with several homogeneous unreliable processors that have limited state information. Each processor receives its own arrival process of tasks from outside users, some of which can be redirected to the other processors. Processing times are iid and arbitrarily distributed. The arrival process of outside tasks to each proces...

Cerebral vasospasm is commonly reported following traumatic brain injury (TBI) and traumatic subarachnoid hemorrhage (tSAH). However, severe vasospasm after TBI with minimal, focal tSAH is rare and often forgotten. A 62-year-old woman experienced an evident mechanical fall with head injury, but with no loss of consciousness or abrasions to the head or neck. She was being treated for hypertensio...

Distributed Shared Memory (dsm) architectures are attractive to execute high performance parallel applications. Made up of a large number of components , these architectures have however a high probability of failure. We propose a protocol to tolerate node failures in two classes of dsm architectures: Cache Only Memory Architectures (coma) and Distributed Virtual Shared Memory (svm) systems. Th...

Application a l'identiication de syst emes et a la mod elisation des s eries chronologiques soutenue le 7 juillet 1997 devant le jury compos e de : Acknowledgements i Acknowledgements I am indebted to Professor Patrick Gallinari, who took me under his supervision in 1992, and followed me throughout this work. I would like him to know that his friendly support during these years were largely ins...

This paper proposes an extension of the multiversion two phase locking protocol, called EMV2PL, which enables update transactions to use versions while guaranteeing the serializability of all transactions. The use of the protocol is restricted to transactions, called write-then-read transactions that consist of two consecutive parts: a write part containing both read and write operations in som...

A method for the p repa ra t ion of H e L a cell p l a sma m e m b r a n e ghosts is descr ibed. The pur i ty of the p l a sma m e m b r a n e f ract ion was examined by phase con t ras t and e lect ron microscopy , by chemica l analysis , and by assay of m a r k e r enzymes. Da ta on the compos i t ion of the p l a sma m e m b r a n e f ract ion are given. It was observed tha t the d is t r ib...

Abstract Over the past two decades several different approaches to defining a geometry over $${{\mathbb F}_1}$$ F1 have been proposed. In this paper, relying on Toën and Vaquié’s formalism (J.K-Theory 3: 437–500, 2009), we investigate new category $${\mathsf {Sch}}_{\wideti...

A macroscop ic n o n i n t e r a c t i v e r e l i a b i l i t y model for ceramic m a t r i x composi tes i s p resented . The model i s m u l t i a x i a l and a p p l i c a b l e t o composi tes t h a t can be c h a r a c t e r i z e d as o r t h o t r o p i c . T e n s o r i a l i n v a r i a n t t h e o r y i s used t o c r e a t e an i n t e g r i t y b a s i s w i t h i n v a r i a n t s...