171 Augmentation of cxcl10 Expression in Nasal Fibroblasts Derived from Patients With Recalcitrant Chronic Rhinosinusitis Associated With Bronchial Asthma Mamoru Yoshikawa, MD, Tsuyoshi Yoshimura, MD, Daiya Asaka, MD, Naoko Okada, PhD, Hirohisa Saito, MD, PhD, and Hiroshi Moriyama, MD. Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan; National Research Instit...

In Drosophila, the eye primordium is specified as a subdomain of the larval eye disc. Here, we show that the Zn-finger transcription factor teashirt (tsh) marks the region of the early eye disc where the eye primordium will form. Moreover, tsh misexpression directs eye primordium formation in disc regions normally destined to form head capsule, something the eye selector genes eyeless (ey) and ...

Carisbamate (CRS) exhibits broad acute anticonvulsant activity in conventional anticonvulsant screens, genetic models of absence epilepsy and audiogenic seizures, and chronic spontaneous motor seizures arising after chemoconvulsant-induced status epilepticus. In add-on phase III trials with pharmacoresistant patients CRS induced < 30% average decreases in partial-onset seizure frequency. We ass...

OBJECTIVES This case-controlled study aimed to identify the association of tumor necrosis factor (TNF)α-1031 and TNFβ+ 252 gene polymorphisms between chronic rhinosinusitis (CRS) and healthy controls. Another purpose of this study was to investigate the associations of these gene polymorphisms with factors related to CRS. METHODS All deoxyribonucleic acid (DNA) samples were genotyped for TNFα...

Allergic rhinitis is a common comorbid condition in pediatric chronic rhinosinusitis (CRS). Testing for aeroallergen sensitization should therefore be considered in the evaluation of children with CRS. At present the aeroallergen sensitivity profile of children with CRS remains uncharacterized. In this study, we retrospectively identify a consecutive series of children with CRS and allergic rhi...

The concept of cognitive reserve emerged from observed disparities between brain pathology and clinical symptoms. It may explain better neuropsychological performance in healthy individuals. The objectives of this study were to measure reserve in healthy subjects using a new Cognitive Reserve Scale (CRS), analyze the internal consistency of the CRS, and analyze validity evidence. A total of 117...

171 Augmentation of cxcl10 Expression in Nasal Fibroblasts Derived from Patients With Recalcitrant Chronic Rhinosinusitis Associated With Bronchial Asthma Mamoru Yoshikawa, MD, Tsuyoshi Yoshimura, MD, Daiya Asaka, MD, Naoko Okada, PhD, Hirohisa Saito, MD, PhD, and Hiroshi Moriyama, MD. Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan; National Research Instit...

OBJECTIVE The current epidemiology of rubella reveals an increase in the number of cases among adult Hispanics and an increase in the number of congenital rubella syndrome (CRS) cases among infants of Hispanic mothers. Recent rubella outbreaks have occurred primarily among adult Hispanics, many of whom are foreign-born natives of countries where rubella vaccination is not routine or has only re...

A novel and efficient transform method for ECG data compression based on B-spline basis functions is proposed. The algorithm allows these basis functions to adapt their shape to the nonstationary behavior of ECG signals. The number and shape of these basis functions are completely characterized by the number and location of the so-called knots. The position of the knots can effectively be coded...