نتایج جستجو برای: complementing group 1 xrcc1 gene

تعداد نتایج: 4202903  

Journal: :Molecular cancer research : MCR 2010
Jimmy M-M Kwok Barrie Peck Lara J Monteiro Helma D C Schwenen Julie Millour R Charles Coombes Stephen S Myatt Eric W-F Lam

The transcription factor Forkhead box M1 (FOXM1) is a key regulator of cell proliferation and is overexpressed in many forms of primary cancers, leading to uncontrolled cell division and genomic instability. To address the role of FOXM1 in chemoresistance, we generated a cisplatin-resistant breast cancer cell line (MCF-7-CIS(R)), which had an elevated level of FOXM1 protein and mRNA expression ...

2017
Xianling Zeng Yafei Zhang Ting Yue Taohong Zhang Junxia Wang Yan Xue Ruifang An

The present meta-analysis was intended to explore the relationship between the X-ray repair cross complementing 1 (XRCC1) polymorphisms (Arg194Trp, Arg280His and Arg399Gln) and cervical cancer risk. Several electronic databases were searched systematically and bibliographies of relevant papers were identified carefully. Then, a meta-analysis was performed based on eligible studies in various ge...

2015
Katarzyna A. Wójcik Ewelina Synowiec Piotr Polakowski Janusz Błasiak Jerzy Szaflik Jacek P. Szaflik

BACKGROUND Fuchs endothelial corneal dystrophy (FECD) is a corneal disease characterized by abnormalities in the Descemet membrane and the corneal endothelium. The etiology of this disease is poorly understood. An increased level of oxidative DNA damage reported in FECD corneas suggests a role of DNA base excision repair (BER) genes in its pathogenesis. In this work, we searched for the associa...

2017
Meng Zhang Wanzhen Li Zongyao Hao Jun Zhou Li Zhang Chaozhao Liang

Polymorphisms in X-ray repair cross-complementing (XRCC) genes have been implicated in altering the risk of various urological cancers. However, the results of reported studies are controversial. To ascertain whether polymorphisms in XRCC genes are associated with the risk of urological neoplasms, we conducted present updated meta-analysis and systematic review. Summary odds ratios (ORs) and co...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003
Ling-Ling Hsieh Huei-Tzu Chien I-How Chen Chun-Ta Liao Hung-Ming Wang Shih-Ming Jung Pei-Feng Wang Joseph Tung-Chieh Chang Min-Chi Chen Ann-Joy Cheng

DNA repair gene polymorphisms have been implicated as susceptibility factors in cancer development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. The 399Gln polymorphism in the DNA repair gene XRCC1 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of cancer development. Two hundr...

Journal: :World journal of gastroenterology 2005
Márcia Cristina Duarte Jucimara Colombo Andrea Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wornrath Ana Elizabete Silva

AIM To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population. METHODS Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150 (C2) controls, respectively. RES...

Journal: :Nucleic acids research 1992
K W Caldecott J D Tucker L H Thompson

The human gene that corrects the DNA repair defect of the CHO cell mutant EM9 is designated XRCC1 and is the first human gene to be cloned that has an established role in DNA strand-break repair. In this study, either an XRCC1 cosmid genomic fragment or synthetic oligonucleotides were ligated to an incomplete XRCC1 cDNA to generate two full-length XRCC1 cDNA constructs. The ability of these min...

Journal: :Folia biologica 2009
R C Sobti S A Mahdi N Berhane S A Hosseini R Kler V Kuttiat A Wanchu

Genetic polymorphisms in DNA repair genes may influence individual variations in the DNA repair capacity. Polymorphisms in the XRCC1 gene that cause amino acid substitutions may impair the interaction of its proteins (XRCC1) with the other enzymatic proteins and consequently alter DNA repair function, which may be associated with the risk of HIV-1/AIDS disease. In this study, we aimed to determ...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Wei-Hong Duan Zhen-Yu Zhu Jun-Gui Liu Mao-Sheng Dong Jun-Zhou Chen Quan-Dda Liu Yu Xie Ti-Ye Sun Ze-Feng Gao Ning-Xin Zhou

PURPOSE Numerous studies have evaluated the association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population. However, the results have been inconsistent. We therefore here examined whether the XRCC1 Arg399Gln gene polymorphism confers hepatocellular carcinoma risk by conducting a meta-analysis. METHODS PubMed, Google scholar and China Nati...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Shan-Yang He Lin Xu Gang Niu Pei-Qi Ke Miao-Miao Feng Hong-Wei Shen

OBJECTIVE We aimed to analyze the association between excision repair cross-complementing rodent repair deficiency complementation group 1 (XRCC1) and ovarian cancer risk. METHODS We performed a hospital-based case-control study with 155 cases and 313 controls in China. All Chinese cases with newly diagnosed primary ovarian cancer between May 2005 to May 2010 in our hospital were invited to p...

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