Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents--soman (GD) and VX. Four commercial detergents were tested as decontamin...

A range of structurally related zwitterionic detergents, Zwittergents 3-06, 3-08, 3-10, and 3-12, and a derivative of cholic acid (Chaps) were examined for their ability to enhance the extraction of newly synthesized, intracellular proteoglycans and for their effect on the functional properties of cartilage proteoglycan. Although none of the detergents could extract greater than 4% of the intra...

We used a class of designed peptide detergents to stabilize photosystem I (PS-I) upon extended drying under N2 on a gold-coated-Ni-NTA glass surface. PS-I is a chlorophyll-containing membrane protein complex that is the primary reducer of ferredoxin and the electron acceptor of plastocyanin. We isolated the complex from the thylakoids of spinach chloroplasts using a chemical detergent. The chlo...

this study is the effects of inhalation toxic mixture of bleach and detergent was examined on the epithelial layer of trachea in the mice. in this study, 42 adult male mice nmri race weighing 35-40 gr and from age 8 to 10 weeks were divided into 6 experimental groups and one control group. experimental groups 1-2-3 with the using of chamber, as inhalation 20 minutes were exposure to spray the a...

We have studied the mechanism by which lysosomotropic detergents kill baby hamster kidney cells. Lysosomotropic detergents are lysosomotropic amines (compounds with pK between 5 and 9, such as imidazole or morpholine) containing straight-chain hydrocarbon "tails" of 9-14 carbon atoms (Firestone, R. A., J. M. Pisano, and R. J. Bonney. 1979, J. Med. Chem., 22:1130-1133). Using lucifer yellow CH a...

The environmental effects of coordination compounds are discussed from the point of view of the introduction of unnatural levels of metal ions and ligands into various parts of the ecosystem. The transport of toxic metals, with special reference to mercury, lead, and cadmium, is described, and the available information on the nature of these metals as they exist in the environment is examined. ...

Investigation on recovery of alkaline protease from B. licheniformis ATCC 21424 fermented wastewater sludge was carried out by centrifugation and ultrafiltration. Optimization of ultrafiltration parameters (transmembrane pressure (TMP) and feed flux) was carried out with 10 kDa membrane. TMP of 90 kPa and feed flux of 714 L/h/m(2) gave highest recovery (83%) of the enzyme from the centrifuged s...

Green chemistry faces a major challenge imposed by the Sustainable Development Goals (6, 14 and 15) defined in 2030 Agenda. In case of cleaning products (detergents), challenges often become paradox: even if it is biodegradable, no surfactant harmless to aquatic life. Compared other studies field, this paper covers ultrasound–detergent interactions beyond cavitation removal process. It also con...

The fluid mosaic model for biological membranes was formulated 40 years ago. Ten years later endosomes were discovered as important prelysosomal organelles. At the outset of my research career, I was fortunate to witness both these turning points in biochemistry and cell biology from close up, and to participate in some of the studies. In this short essay, I will describe how this came about, a...