In an effort to develop a quantitative ligand-binding model for the receptor tyrosine kinases, a pharmacophore search was first used to identify structural features that are common in two novel sets of 12 molecules of the 3-substituted indolin-2-ones and 19 compounds of the benzylidene malononitriles with low-to-high affinity for HER2, a kind of receptor tyrosine kinase. The common pharmacophor...

The quantitative structure-activity relationship (QSAR) analysis with comparative molecular field analysis (CoMFA) of indole derivatives-monoamine oxidase (MAO) inhibitors were done. The pharmacophore model included four features: two hydrophobic rings, one donor atom, and one acceptor site. The predictive values (cross-validated r2) of QSAR analysis for the inhibition of MAO-A and MAO-B were 0...

We demonstrate the existence and stability of bright vortex solitons sustained by a ring-shaped parametric gain, for both focusing and defocusing Kerr nonlinearities in lossy optical media. With the defocusing nonlinearity, the vortices are stable at all values of the detuning parameter, while under the focusing nonlinearity their stability region is limited to some positive values of the detun...

The p=0 term of the Mie-Debye scattering amplitude contains the effects of external reflection and diffraction. We computed the reflected intensity in the time domain as a function of the scattering angle and delay time for a short electromagnetic pulse incident on a spherical particle and compared it to the predicted behavior in the forward-focusing region, the specular reflection region, and ...