Ursolic acid (UA), a naturally occurring pentacyclic triterpene acid found in many medicinal herbs and edible plants, triggers apoptosis in several tumor cell lines but not in human bone cancer cells. Most recently, we have demonstrated that UA exposure reduces the viability of human osteosarcoma MG-63 cells through enhanced oxidative stress and apoptosis. Interestingly, an inhibitor of osteocl...

5-Aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has the potential to kill cancer cells via apoptotic or necrotic signals that are dependent on the generation of intracellular reactive oxygen species (ROS). Celecoxib is an anti-inflammatory drug that induces intracellular ROS generation. We investigated whether the combined application of celecoxib and ALA-PDT improved the efficacy ...

The present study investigated the role of mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the expression of habituation of the hypothalamic-pituitary-adrenal (HPA) axis response to stress. Male rats were restrained for 1 h per day for six consecutive days. On day 6, 1 h prior to restraint stress, both restraint-naive and repeatedly restrained rats were injected s.c. with ...

The analysis of pavements and their ingredients has always been important due to a good understanding of their behavior under different conditions; that leads to more accurate relations. Due to the extent of asphalt mixture application in the world, the assessment of different behaviors of this mix is very important from various aspects of performance and safety. Given that the asphalt mixtures...

Shade and drought commonly occur together in turfgrass systems due to competition with trees for light soil water. Two greenhouse studies were conducted evaluate the effects of combined shade stress on bermudagrass [Cynodon dactylon (L.) Pers.] hybrid [C. Pers. × C. transvaalensis Burtt Davy] physiology. ‘Latitude 36 Turf Bermudagrass’ (Latitude 36TM) ‘Riley's Super Sport’ (Celebration®) select...