1. Pemberton JH, Rath DM, Ilstrup DM. Evaluation and surgical treatment of severe chronic constipation. Ann Surg 1991;214:403-11. 2. Nam YS, Pikarsky AJ, Wexner SD, Singh JJ, Weiss EG, Nogueras JJ, et al. Reproducibility of colonic transit study in patients with chronic constipation. Dis Colon Rectum 2001;44:86-92. 3. Kamm MA, Hawley PR, Lennard-Jones JE. Outcome of colectomy for severe idiopat...

Mouth-caecum transit time (M-CTT) of a lactulose labelled liquid test meal has been measured in 27 coeliac patients and 10 healthy controls using the breath hydrogen technique. Although all patients were urged to maintain a gluten free diet, not all did, and there was, therefore, a wide range in the severity of fat malabsorption within the patient group. Gastric emptying of a 113Indium DTPA-lab...

Camilleri M, Carlson P, McKinzie S, Grudell A, Busciglio I, Burton D, Baxter K, Ryks M, Zinsmeister AR. Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation. Am J Physiol Gastrointest Liver Physiol 294: G13–G19, 2008. First published October 25, 2007; doi:10.1152/ajpgi.00371.2007.—Cannabinoid agonist inhibits gastrointestinal motility. The endocannabinoid, a...

We evaluated performance of a modified Combat Task Test (CTT) and of standard fitness tests in 20 male subjects to assess the prediction of occupational performance standards for Kennedy Space Center fire fighters. The CTT consisted of stairclimbing, a chopping simulation, and a victim rescue simulation. Average CTT performance time was 3.61 +/- 0.25 min (SEM) and all CTT tasks required 93% to ...

Cannabinoid agonist inhibits gastrointestinal motility. The endocannabinoid, anandamide, is inactivated by fatty acid amide hydrolase (FAAH). A single nucleotide polymorphism in the human FAAH gene (C385A) reduces FAAH expression. Our aim was to evaluate associations between FAAH genotype variation and symptom phenotype, gastric emptying and volume, colonic transit, and rectal sensation in pati...

We recently reported that immobilization stress increased colonic motility, mucin, and prostaglandin E2(PGE2) release and mucosal mast cell degranulation in rat colon [ Proc. Natl. Acad. Sci. USA 93: 12611-12615, 1996; Am. J. Physiol. 271 ( Gastrointest. Liver Physiol. 34): G884-G892, 1996]. To directly assess the contribution of mast cells, we compared colonic responses to stress in mast cell-...

OBJECTIVE To examine the dynamics of intracranial venous flow patterns in patients with idiopathic intracranial hypertension (IIH). METHODS Nonrandomized controlled trial analyzing the difference in cerebral perfusion in 13 IIH patients and 12 healthy controls using contrast-enhanced duplex sonography. In patients, an additional 3D gradient echo magnetic resonance venography (MRV) using a new...