•Occult ovarian carcinoma of presumable fallopian tube origin in Lynch syndrome•Atypical endometrial hyperplasia during a 10-year follow-up period after colon cancer•Synchronous ovarian serous carcinoma in situ and borderline tumor in Lynch syndrome.

Introduction Medullary carcinoma is a rare type of colorectal adenocarcinoma, and omental infarction is a rare cause of acute abdomen. Presentation of case A 72-year-old woman underwent single-incision laparoscopic right hemicolectomy for ascending colon cancer. Pathological examination showed a medullary carcinoma (MC) of T4aN0M0 Stage IIB. Her postoperative course was uneventful, and she wa...

BACKGROUND Vincristine (VCR) is a chemical that is widely used in tumor therapy. While long-term use can make tumor cells resistant to VCR, the underlying mechanisms of this resistance are still unclear. OBJECTIVE This study aimed at investigating the role of microRNA (miRNA) in colon cancer drug resistance. METHODS HCT-8 colon carcinoma cells were cultured and treated with different VCR co...

Mutations involving the adenomatous polyposis coli (APC) tumor suppressorgene/beta-catenin signaling pathway have been identified in the majority of colon carcinomas. However, the role of aberrant beta-catenin signaling in the neoplastic growth of APC-mutant colon cancer cells has not been directly studied. To address this question, antisense oligonucleotides have been used to specifically down...

Colorectal cancer (CRC) is one of the leading causes of cancer-associated mortality worldwide. There is increasing evidence that microRNAs (miRNAs) are involved in development and progression of colorectal carcinoma. miR-145 is a tumor suppressor and has been confirmed as a negative regulator of colorectal cancer. Although multiple target genes have been identified for miR-145, the molecular me...

A man with metastatic carcinoma of the colon had a bone scan which revealed urinary retention in the left kidney. Ten months later, a Tc-99m-DTPA renai glomerular study showed the left kidney to have only 8% of total renal function. Fifteen months after that, (he same kidney demonstrated 9% of total function, while the right kidney had evolving obstruction due to his neoplasm. The case sh...

The epidermal growth factor receptor (EGFR) is overexpressed in 50-70% of human primary breast, lung, and colon carcinomas, whereas it is not usually expressed in hematopoietic cells. We developed a novel reverse transcription-PCR (RT-PCR)-Southern blot assay for the detection of circulating, EGFR mRNA-expressing tumor cells in carcinoma patients. The assay was set up by increasing the amount o...

New Pd(II) complexes of 1,7-bis(2-methoxyphenyl)hepta-1,6-diene-3,5-dione were synthesized and structurally characterized. The complexes were tested in vitro on human colon and hepatic carcinoma cell lines, normal hepatic cells and hematopoietic progenitor cells. Biological tests proved that Pd(II) complexes 1 and 2 (containing a curcumin derivative) exhibit a strong in vitro antitumor effect a...

Crohn's disease is not usually regarded as a premalignant state. Recent reviews of the literature1' 2 make scant reference to an association of regional enteritis with carcinoma. However, at the World Congress of Gastro-enterology, I958, Crohn observed that he had seen two cases of carcinoma of the small intestine co-existing with regional enteritis.3 Rare cases of carcinoma arising in patients...