نتایج جستجو برای: colon cancer

تعداد نتایج: 948671  

2016
Vi K. Chiu Anne-France Le Rolle

incidence of cancer increases exponentially with age. Aging may lead to pathologies due to the physiologic decline or aberrancy in the functions of adult stem cells, whose intrinsic capacity for self-renewal helps maintain tissue homeostasis. The majority of cancers arise from replication-induced somatic mutations in adult stem cells [1], which predisposes to hijacking their self-renewal pathwa...

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Journal: :International journal of clinical and experimental pathology 2015
Ke Yang Feng Wang Jian-Jun Han

The tumor necrosis factor receptor-associated factor 4 (TRAF4) has been linked to carcinogenesis. However, the role of TRAF4 in colon cancer is still unclear. Therefore, we investigated the role of TRAF4 in colon cancer and the underlying mechanism. In the present study, we found that TRAF4 was overexpressed in colon cancer tissues and cells, and small interfering RNA (siRNA)-mediated gene knoc...

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2014
Ozgür Bostancı Ozgür Kemik Ahu Kemik Muharrem Battal Uygar Demir Sevim Purisa Alpaslan Yavuz Mehmet Mihmanlı

BACKGROUND Screening for biochemical markers is important for diagnosing colon cancer. In this study, the reliability of serum mesothelin levels as a potential diagnostic and screening instrument was evaluated concerning colon cancer. METHODS Ninety-five patients who had undergone colonoscopic examination and who were diagnosed with colon cancer were included in the study. The serum mesotheli...

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Journal: Iranian Journal of Blood and Cancer 2016
Robab Sheikhpour,

Cancer is one of the most fatal diseases in human beings which annually leads to death of 30000 individuals in Iran. Prevention, diagnosis and treatment of cancer is one of the major scientific challenges all around the world. It seems that increased incidence of several cancers such as colon and prostate and their mortality are connected with obesity. It is suggested that obesity and metabolic...

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Journal: Journal of Kerman University of Medical Sciences 2020
Amir Mobasserfar, Behjat Kalantari Khandani, Mohammad Hashemi, Mohammad Javad Zahedi, Mohammad Mahdi Hayatbakhsh Abbasi Sara Shafieipour, Sodaif Darvish Moghadam,

Background: Single nucleotide polymorphisms (SNPs) have been introduced as a new genomic source for cancer. Therefore, it was decided to conduct a study to evaluate the rs3746444 polymorphism of miR-499 in patients with colon cancer in comparison with healthy subjects. Methods: This case-control study was conducted to investigate rs3746444 polymorphism of miR-...

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Journal: مجله بین المللی علوم آزمایشگاهی 2018
Arezoo Faramarzi, Mohammadali Hosseinpourfeizi, Reza Safaralizadeh, Yaghoub Moaddab,

Background and Aims: An impairment of expression in MLL2 gene involved in histone methylation induces alteration in the methylation patterns at enhancers and causes several cancers including colon cancer. In this study, MLL2 expression was evaluated in North West of Iran. Materials and Methods: To evaluate the MLL2 expression in patients with colon cancer, 25 tumor samples and 25 samples of tu...

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Journal: :Biochemical and biophysical research communications 2014
Amr A Al-Haidari Ingvar Syk Henrik Thorlacius

BACKGROUND Simvastatin is widely used to lower cholesterol levels in patients with cardiovascular diseases, although accumulating evidence suggests that statins, such as simvastatin, also exert numerous anti-tumoral effects. AIM The aim of this study was to examine the effect of simvastatin on colon cancer cell migration. METHODS Migration assays were performed to evaluate CCL17-induced col...

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2016
TIANQI ZHANG JINING FU YUETING LI YAOHUI WANG LONG ZHANG YING LIU

Environmental and genetic factors interact in the process and treatment of colon cancer, although the underlying mechanisms remain elusive. The aim of the study was to examine the role of whether bone morphogenetic protein 7 (BMP7) is involved in the progression of colon cancer under local intratumoral infiltration lymphocytes. A total of 46 cases of pathologically confirmed specimens were obta...

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Journal: Iranian Journal of Nuclear Medicine 2021
Armaghan Fard-Esfahani, Babak Fallahi, Bahare Saidi, Mohammad Eftekhari, Najme Karamzade-Ziarati,

Management of locally advanced colon cancer metastases is challenging and operation carries an increased risk of morbidity and mortality. The knowledge of exact sites of involvement can aid the surgeon to make a decision regarding complete resection or palliative therapy. PET/CT scan is an advantage in this setting because metabolic alterations often precede the anatomic changes; moreover, it c...

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2014
Sang Hyun Park Chi Wook Song Yun Bae Kim Young Sun Kim Hwang Rae Chun Jung Hyun Lee Won Jong Seol Hyung Sun Yoon Myung Kwon Lee Jong Hyup Lee Choon Sang Bhang Jae Hyung Park Ji Young Park Byung Hun Do Young Dae Park Sang Jeong Yoon Chan Wook Park Su Mi Yoon Jong Hwan Choi Ki Chul Shin Dong Hoon Ko Young Jin Kim Dong Choon Seol

BACKGROUND/AIMS The purpose of this study was to evaluate the clinicopathologic characteristics of colon cancers detected at the SOK Sokpeynhan Internal Medical Network, a nationwide system of primary health care institutions. METHODS We analyzed 579 colon cancer patients diagnosed using colonoscopy at the SOK network from January 2011 through December 2012. Cancers from the rectum to the spl...

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