OBJECTIVES The objective of this study was to apply a pharmacokinetics-pharmacodynamics approach to investigate the free propofol plasma levels in patients undergoing coronary artery bypass grafting under hypothermic conditions compared with the off-pump procedure. METHODS Nineteen patients scheduled for on-pump coronary artery bypass grafting under hypothermic conditions (n=10) or the equiva...

Background: Recent evidence suggests that regular exercise training is effective in treating various aspects of cancer. Therefore, the purpose of this study was to determine the effect of 8 weeks of aerobic interval training on monocarboxylate transporter 1 (MCT1) protein and expression of p53 gene in tumor of colon cancer mice. Methods: The present study was conducted experimentally from May ...

background: solid tumors may occur in 3% of the patients with chronic myeloid leukemia (cml). in this paper, we presented a case of cml following treatment of colon cancer. case presentation: a 25 year old man was diagnosed of adenocarcinoma of rectosigmoid treated with fluorouracil-based chemotherapy. following relapse, he received florouracil, oxaliplatin and irinotecan during the next year. ...

conclusions we have found significant associations between lifestyle factors (alcohol consumption and smoking) and mental health problems (depression and insomnia) and crc screening uptake. to improve overall crc screening uptake in the us, it is important to consider racial differences in predictors and tailor appropriate interventions to each racial/ethnic group. background mortality from col...

a 78-year-old woman with a history of colon cancer with metastasis to the liver was presented to our emergency department because of bilateral groin pain and difficulty in walking, which had gradually increased during the previous 5 days. the pain was of sudden onset, radiating to the back, without aggravating or relieving factors. it was associated with constipation, dysuria and vaginal discha...

background and objective: the management of apoptotic cell death has been considered as a putative therapeutic strategy for cancer treatment. in the present study we investigated the putative pro-apoptotic effect of allicin, the main garlic organosulfur component with repeatedly claimed chemopreventive potency, on the human adenocarcinoma cell line ht29 as an apoptosis resistant cell line, in v...

background and objectives: involvement of lymph nodes is an important prognostic factor in the most cancers, including colorectal cancer. in the recent years, invasion to blood and lymphatic vessels has been shown to predict involvement of lymph nodes and the number of involved nodes has been less studied issue. the aim of this study was determination of the relationship between the size of col...