Background and Aim. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with irritable bowel syndrome (IBS). Methods. The present study was undertaken to evaluate the density of duodenal CgA as a biomarker for the diagnosis of IBS. Two hundred and three patients with IBS were recruited (180 females and 23 males; mean age, 36 year...

Background Preterm labor is a major cause of perinatal morbidity and mortality and it might be predicted by assessing the cervical change. Objective To assess the association between absence of cervical gland area (CGA) and spontaneous preterm labor (SPTL). Materials and Methods This prospective cohort study was performed on 200 singleton pregnant women with a history of SPTL, second-trimes...

Two novel monoclonal antibodies, called B11 and B13, directed exclusively against human chromogranin B (CgB) and another antibody, A11, specific for human chromogranin A (CgA), were obtained by immunization of mice with chromaffin granules, the fusion of their splenocytes, the screening of hybridomas supernatants by ELISA and immunohistochemistry, and characterization of the antibodies by two-d...

BACKGROUND Elderly patients with advanced non-small-cell lung cancer (NSCLC) may derive similar benefit from platinum-based chemotherapy as younger patients. Quality of life (QoL) and comprehensive geriatric assessment (CGA) is often advocated to assess benefits and risks. PATIENTS AND METHODS A total of 181 chemotherapy-naive patients [≥70 years, performance score (PS) of 0-2] with stage III...

Cardiovascular risk assessment remains difficult in elderly patients. We examined whether chromogranin A (CgA) measurement in plasma may be valuable in assessing risk of death in elderly patients with symptoms of heart failure in a primary care setting. A total of 470 patients (mean age 73 years) were followed for 10 years. For CgA plasma measurement, we used a two-step method including a scree...

AIM To correlate the baseline and change of chromogranin A (CgA) levels with patient survival and tumor response in Asian patients with advanced gastro-enteropancreatic neuroendocrine tumors (GEP-NETs). PATIENTS AND METHODS Sixty patients with advanced GEP-NET treated in a medical center between April 2010 and April 2013 were enrolled retrospectively. Plasma CgA level was analyzed for correla...

In previous papers [1,2] relating to the concept of Combined Gravitational Action (CGA) we have established the CGA-theoretical foundations as an alternative gravity theory that already allowed us to resolve -in its contextsome unexpected and defiant problems occurred inside and outside the Solar System like, e.g., the anomalous Pioneer 10’s deceleration; the observed secular increase of the As...

The compact Genetic Algorithm (cGA) is an Estimation of Distribution Algorithm that generates offspring population according to the estimated probabilistic model of the parent population instead of using traditional recombination and mutation operators. The cGA only needs a small amount of memory; therefore, it may be quite useful in memory-constrained applications. This paper introduces a theo...

OBJECTIVES To construct and validate a frailty index (FI) that is clinically sensible and practical for geriatricians by basing it on a routinely used comprehensive geriatric assessment (CGA) instrument. DESIGN Secondary analysis of a 3-month randomized, controlled trial of a specialized mobile geriatric assessment team. SETTING Rural Nova Scotia. Participants were seen in their homes. PA...

PURPOSE To evaluate whether the pretreatment determination of serum chromogranin A (CgA) can provide information beyond that obtained with serum prostate specific antigen (PSA) and Gleason score at biopsy as a predictive factor of clinical understaging (T2-pT3) of prostate adenocarcinoma. MATERIALS In this prospective study, we analyzed 83 consecutive patients with clinical T2N0M0 prostate ad...