Abstract: Phillips and Silverstein argue that a range of cognitive disturbances in schizophrenia result from a deficit in cognitive coordination attributable to NMDA receptor dysfunction. We suggest that the viability of this hypothesis would be further supported by explicit implementation in a computational framework that can produce quantitative estimates of the behavior of both healthy...

Evidence suggests that transcranial direct current stimulation (tDCS) modulates conditioned fear memories and has effects on cognitive flexibility via the dopaminergic system. This study examines whether modulation of scopolamine-induced memory deficit by anodal tDCS could be mediated The male NMRI mice received scopolamine, 30 min before conditioning, showed impaired contextual retention. Mice...

Dysfunctions in affective experience reflect a pernicious feature of schizophrenia-spectrum pathology that are largely intractable under current treatment regimens. Of note, individuals with schizophrenia show robust and marked deficits in the experience of pleasure when assessed using "trait" measures of affect (i.e., trait questionnaires and clinical interview), but fail to demonstrate this a...

Motor performance and cognitive function were examined in depressed patients and controls. Increasing severity of depression was strongly associated with decrements in performance in both motor and memory tasks. Greatest depression-related impairment was found on those cognitive and motor tasks that required sustained effort. We discuss these results in terms of a generalized deficit in the cen...

This longitudinal study investigates the relation between recall memory and communication in infancy and later cognitive development. Twenty-six typically developing Swedish children were tested during infancy for deferred imitation (memory), joint attention (JA), and requesting (nonverbal communication); they also were tested during childhood for language and cognitive competence. Results show...

This article begins with a brief description of the guiding theory behind cognitive-behavioral interventions with youth, such as a therapeutic posture, an important cognitive distinction, and a specific treatment goal. Next, on the basis of a review of the literature, the nature of cognitive functioning, the treatments, and the outcome of treatment studies are described and examined for (a) agg...

Working memory (WM) deficit is a cardinal cognitive symptom of schizophrenia, but the differences among the tasks and measures used to assess WM make it difficult to compare across studies. The authors conducted a meta-analytic review to address 3 major questions: (a) Do patients with schizophrenia show WM deficits across diverse methodology; (b) Is WM deficit supramodal; and (c) Does the WM de...

Naringenin is a flavonoid polyphenolic compound, which facilitates the removal of free radicals, oxidative stress and inflammation. The present study aimed to obtain a better understanding of the effects of curcumin on the regulation of diabetes‑associated cognitive decline, and its underlying mechanisms. An experimental diabetes mellitus (DM) rat model was induced by streptozoticin (50 mg/kg)....

As humans navigate through daily life, their visual systems constantly encounter more stimuli than they can process in real time. To overcome this issue, humans acquire relevant visual information selectively and sequentially using gaze fixations. Understanding the patterns of these fixations is the topic of many cognitive studies on human visual attention. In this paper, we try to give a broad...