Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning immune system. These include its essential role as an electron carrier mitochondrial respiratory chain, enabling process oxidative phosphorylation to occur with concomitant production ATP, together potential lipid-soluble antioxidant, protecting against free radical-induced oxidation. Furt...

Background: The aim of this study was to evaluate seminal plasma coenzyme Q10 levels and oxidative stress in patients with different types of male infertility. Materials and Methods: The study took place in the Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University- Baghdad-Iraq from the period of November 2004 till July 2006. Sixty patients with male infertility w...

Plasma coenzyme Q10 (CoQ10) response to oral ingestion of various CoQ10 formulations was examined. Both total plasma CoQ10 and net increase over baseline CoQ10 concentrations show a gradual increase with increasing doses of CoQ10. Plasma CoQ10 concentrations plateau at a dose of 2400 mg using one specific chewable tablet formulation. The efficiency of absorption decreases as the dose increases....

UNLABELLED Our aim was to report a new case with cerebellar ataxia associated with coenzyme Q10 (CoQ) deficiency, the biochemical findings caused by this deficiency and the response to CoQ supplementation. PATIENT A 12-year-old girl presenting ataxia and cerebellar atrophy. BIOCHEMICAL STUDIES: Coenzyme Q10 in muscle was analysed by HPLC with electrochemical detection and mitochondrial respir...