We appreciate the comments by Dr O’Connell and colleagues on our article published in CHEST 1 describing the cumulative incidence and pretransplant risk factors for post-lung transplant renal dysfunction in adult patients with cystic fi brosis (CF). We agree that serum creatinine concentration alone should not be relied upon solely to assess renal function in CF because of its poor sensitivity....

BACKGROUND Cystatin C is a low molecular weight protein produced by all nucleated human cells, with a stable production rate. Its levels are not influenced by inflammation, infections, hepatic or renal diseases, or by dietary or constitutional factors. We compared serum cystatin C and serum creatinine based predicting equations to estimate glomerular filteration rate (GFR) in type 2 diabetes me...

Background. Serum creatinine (Scr)-based equations lack accuracy in predicting glomerular filtration rate (GFR) in patients with liver disease. Cimetidine has been shown to improve the performance of Scr-based GFR formulae. Methods. We evaluated the use of cimetidine on the performance of GFR-estimating equations in 39 liver transplant recipients. The patients received oral cimetidine (800 mg t...

Background Rapid and accurate estimation of the glomerular filtation rate (GFR) is required for many major clinical decisions in patients with chronic nephropathies [1]. Direct GFR measurement is time-consuming and expensive, frequently requires urine collection and isotope use, and is routinely available in only a few medical centers [1]. In clinical practice, GFR is usually estimated from the...

AIM To compare the performance of iohexol plasma clearance and creatinine-based renal function estimating equations in monitoring longitudinal renal function changes in chronic heart failure (CHF) patients, and to assess the effects of body composition on the equation performance. METHODS Iohexol plasma clearance was measured in 43 CHF patients at baseline and after at least 6 months. Simulta...

Chronic Kidney Disease (CKD) is a very common clinical problem in elderly patients and associated with increased morbidity mortality. The proportion of the predicted to further rise 20% by year 2030 caused demographic change from pattern high birth rates mortality low rates. Delayed has contributed population. aging process involves physiological nutritional changes that will affect status elde...