the aim of this study was to identify and prioritize the risky behaviors and explore the newly emerging pi related to egyptian habits that may lead to hcv transmission.from january 2011 until january 2012, a case control study matched on socio demographic factors was conducted comparing 540 hepatitis c patients and their contacts who were hcv serologically negative (102 subjects). they were ran...

Hemophilia B is a rare blood coagulation disorder. Complications such as bleeding and hematoma can cause necrosis of flaps, wound disruption, and the disturbance of wound healing. In particular, guidelines for flap operations in hemophilia B patients have still not been defined, and case reports are rare. We reconstructed the heel of a 41-year-old male hemophilia B patient using a reverse sural...

As fresh frozen plasma (FFP) loses coagulation factor activity during the production process, FFP therapy may not be feasible to completely replenish coagulation factor concentrations in a clinical setting. The aim of this study was to describe the results of early replacement coagulation factors with FFP in a simplified and idealized in vitro model of dilution. Six ml of whole blood drawn from...

Introduction: Andropause is a common clinical entity of advanced age, with a decline in androgen levels in males. Many of the signs of male aging are results of this condition with significant decline in their quality of life and adverse effects on multiple organ systems function. Androgen Deficiency of the Aging Male (ADAM) questionnaire is one of the most applied screening tools for androgen ...

Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority being multifactorial, with multiple genetic and environmental risk factors of smal...

Atrial fibrillation (AF) and venous thromboembolism (VTE) are the two most common medical conditions managed with anti-coagulation therapy. Not all the patients with decreased mobility or AF have a similar risk for thromboembolism. The risk factors for venous thromboembolism and thromboembolism associated with AF are described in various studies. Considering that the two conditions have similar...

The coagulation/fibrinolysis system is essential for wound healing after vascular injury. According to the standard paradigm, the synthesis of most coagulation factors is restricted to liver, platelets and endothelium. We challenged this interpretation by measuring coagulation factors in nine human primary cell types. FX mRNA was expressed by fibroblasts, visceral preadipocytes/adipocytes and h...

Several haemostatic abnormalities have been reported in thyroid hormone excess. However, the overall effect on coagulation and fibrinolysis is still unclear. We were presented the unique opportunity to further explore the effects of excessive levels of thyroid hormone in the case of a young woman who attempted suicide by auto-intoxication with levothyroxine. Levels of thyroid hormones and param...

The safest and most practical method of administering long-term anticoagulants in pregnancy is uncertain because treatment of the mother with vitamin K antagonists may be complicated by hemorrhage in the fetus. The effects on the fetus of giving coumadin in pregnancy was evaluated in rabbits. When coumadin was given from early pregnancy until term, all of the fetuses were stillborn with widespr...

www.chestjournal.org CHEST / 137 / 1 / JANUARY, 2010 185 C about the risk of bleeding in critically ill patients are common. This apprehension may stem from a sense of responsibility for bleeding following procedures or anticoagulant therapy, or perhaps the fact that hemorrhage is often visible externa lly. In addition, the clinical laboratory may raise awareness by offering tests that clinicia...