We present a technique for fabricating hydrophobic drug nanoparticles using a microfluidic spray dryer. The nanoparticles are formed by evaporative precipitation of the spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles are yielded with narrow size distribution, 20-60 nm in diameter. As the device geometry allows us to inject two separate solvent streams, t...

Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate p...

objective(s): according to the unique properties of magnetic nanoparticles, their usages in medicine and industry have increased in the last decade. due to the vital role of liver in the body, the accumulation of cofe2o4 and cofe2o4@dmsa was studied. materials and methods:the nanoparticles were synthesized by co-precipitation method and were coated with dmsa. the techniques xrd, tem, dls, ftir,...

The present study discusses evaluation of pullulan-functionalized doxorubicin nanoparticles for asialoglycoprotein receptor-mediated uptake in the Hep G2 cell line. Doxorubicin hydrochloride (DOX) nanoparticles using polymers of different hydrophobic character, polyethylene sebacate (hydrophobic) and poly (lactic-co-glycolic acid) (intermediate hydrophobicity) with high entrapment efficiency an...

We present a template-free method for "polymerizing" nanoparticles into long chains without side branches. A variety of nanoparticles are encapsulated in polystyrene-block-poly(acrylic acid) (PSPAA) shells and then used as monomers for their self-assembly. Spherical PSPAA micelles upon acid treatment are known to assemble into cylindrical micelles. Exploiting this tendency, the core-shell nanop...

The production and use of iron oxide nanoparticles are growing exponentially due to its wide applications in different fields of science and technology. The objective of this study is to synthesize iron oxide nanoparticles, and modification of its surface to make it less toxic. The iron oxide nanoparticles were synthesized by chemical co-precipitation method, and surface modification was done u...

Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly(DL-lactide-co-glycolide) [DexbLG] for antitumor drug delivery. Sorafenib-incorporated nanoparticles were prepared by a nanoprecipitation-dialysis method. Sorafenib-incorporated DexbLG nanoparticles were uniformly distributed in an aqueous solution regardless of the content of sorafenib...

In this study, Nd-doped cobalt oxide (Nd-Co3O4) nanoparticles were prepared by a combustion synthesis procedure using Co(acac)3 complex. The nanoparticles were characterized by infrared spectroscopy (IR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Then, the effect of Nd-Co3O4 ...

As the tumor microenvironment (TME) develops, it is critical to take the alterations of pH value, reduction and various enzymes of the TME into consideration when constructing the desirable co-delivery systems. Herein, TME pH and enzyme dual-responsive core-shell nanoparticles were prepared for the efficient co-delivery of chemotherapy drug and plasmid DNA (pDNA). A novel pH-responsive, positiv...

lu3+/yb3+ and lu3+/er3+ co-doped sb2se3 nanomaterials were synthesized by a co-reduction method in hydrothermal condition. powder xrd patterns indicate that the lnxln′xsb2-2xse3 ln: lu3+/yb3+ and lu3+/er3+ crystals (x= 0.00-0.04) are isostructural with sb2se3. the cell parameters were increased for compounds upon increasing the dopant content (x). sem and tem images show that co-doping of lu3+/...