Fibroblast growth factor receptor 1 (FGFR1) has been noted to be amplified in a variety of squamous cell carcinomas (SCCa) of the head, neck, and lung and increased copy number (CN) is a predictor of poor outcomes. FGFR1 is a therapeutic target for lung SCCa and inhibition therapy is currently in clinical trials. Absolute quantification of FGFR1 from formalin fixed paraffin embedded (FFPE) tiss...

The reaction of cyanide, carbon monoxide, and ferrous derivatives led to the isolation of three products, trans- and cis-[Fe(CN)(4)(CO)(2)](2)(-) and [Fe(CN)(5)(CO)](3)(-), the first two of which were characterized by single-crystal X-ray diffraction. The new compounds show self-consistent IR, (13)C NMR, and mass spectroscopic properties. The reaction of trans-[Fe(CN)(4)(CO)(2)](2)(-) with Et(4...

Cocatalyst decoration has been recognized as an effective strategy in photocatalysis, yet the critical role of sing-atomic state on CO2 photocatalytic reduction, distinguished from oxide and elemental states, remains a mystery hitherto. Herein, single-atom Pd (Pd-SA), oxides (PdOx), nanoparticles (Pd-NP), were homogeneously anchored g-C3N4 (CN) to investigate their reduction behaviors under vis...

The hydration of phosphate ions, an essential component many biological molecules, is studied using all-atom molecular dynamics (MD) simulation and quantum chemical methods. MD simulations are carried out by employing a mean-field polarizable water model. A good linear correlation between the self-diffusion coefficient anion concentration ascertained from computed mean-square displacement (MSD)...

Cryptococcus neoformans (Cn) is a pathogenic yeast and the cause of cryptococcal meningitis. Prevalence of disease between males and females is skewed, with males having an increased incidence of disease. Based on the reported gender susceptibility differences to Cn in the literature, we used clinical isolates from Botswanan HIV-infected patients to test the hypothesis that different gender env...

BACKGROUND Net atrioventricular compliance (Cn) has been reported to be an important determinant of pulmonary hypertension in mitral stenosis (MS). We hypothesized that it may be useful in assessing prognosis because Cn reflects hemodynamic consequences of MS. To date, limited data with an assumed Cn cutoff have indicated the need for larger prospective studies. This prospective study was desig...

A moderately stable hexacoordinated sulfur(VI) compound with four different kinds of ligands, CF3SF2(CN)2C1, results when CF3SF4CI is reacted with (CH3)3SiCN. The latter compound also gives F2S(CN)2 and (CF3)2S(CN)2 with SF4 and (CF3)2SF2, respectively. These tetracoordinated suifur(IV) compounds decompose rapidly at 25 °C but are stable at lower temperatures. With OSCl2 and SC12, the white sol...