BACKGROUND AND PURPOSE Congenital nystagmus (CN) is an ocular oscillation that usually manifests during early infancy. Typical features of CN include bilateral, conjugate, uniplanar, and usually horizontal eye movements, a null position, increased oscillation during fixation, and decreased amplitude during convergence. Our purposes were description and analysis of clinical and oculomotor findin...

A vertex irregular total k-labeling of a graph G with vertex set V and edge set E is an assignment of positive integer labels {1, 2, ..., k} to both vertices and edges so that the weights calculated at vertices are distinct. The total vertex irregularity strength of G, denoted by tvs(G)is the minimum value of the largest label k over all such irregular assignment. In this paper, we study the to...

The coordination number (CN) is an important structure property of liquid metals. A simple yet extremely precise method for calculating CN proposed, the classical methods are evaluated systematically, and mathematical forms symmetry corrected. Using Gaussian function construct, first shell pair distribution (PDF), right-hand side peak extrapolated, expression simplified with a to obtain its non...

Fine tuning of blend morphology is a key factor that limits the performance bulk-heterojunction organic photovoltaics (BHJ-OPVs). Herein, morphological control binary (PM6:Y7) and ternary (PM6:Y7:PC70BM) blends conducted through 1-chloronaphthalene (CN) solvent additive thermal annealing (TA) treatment with respect to their influence on photovoltaic performance. Moreover, distinct study accompl...

Cernitin pollen extract (CN-009), extract from several pollen species, has been used for urinary dysfunction. As its mode of action has not been clarified, we investigated the action of CN-009 on the isolated bladder smooth muscles of rats, guinea pigs and cats and the intravesical pressure in female rats. CN-009 contracted isolated detrusor muscles of rats, guinea pigs and cats in a concentrat...

Two bimetallic assemblies K[Cu(cyclam)][Fe(CN)6] 4H2O 1 and [Cu(L)][Cu(L )][Fe(CN)6] 6.5H2O 2 (cyclam = 1,4,8,11-tetraazacyclotetradecane; L = N,N -bis(2-pyridylmethylene)-1,3-propanediamine and L = N-2-pyridylmethylene-1,3-propanediamine) have been prepared from the reaction of [Fe(CN)6] 3 and the precursors [Cu(cyclam)] and [Cu(L)] , respectively, and their structure and magnetic properties s...

Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin-immunosuppressant complexes, cyclophilin A-cyclosporin A (CyPA-CsA) and FKBP-FK506. How the two structurally distinct immunophilin-drug complexes bind the same target has remained unknown. We report the crystal structure of calcineurin (CN) in complex with CyPA-CsA at 2.8-A resolution. The Cy...

PURPOSE Retinoblastoma, a childhood cancer of the retina, is caused by inactivation of the tumor suppressor gene retinoblastoma (RB). Cotylenin A (CN-A), a novel fusicoccane-diterpene glycoside, accelerates the differentiation of several types of myeloid cell lines and is a candidate for a new type of anticancer therapeutic agent with this effect. However, whether CN-A has the same effect on re...

Camptothecin (CN) is active against several experimental tumors and has also been studied clinically. We report here the effect of CN on LI210 cells and asynchronous and synchronous DON cells in culture. CN was toxic both to LI210 cells (0.06 ¿ig/ml,2-hr exposure) and DON cells (0.15 Mg/ml, 1-hr exposure), and it inhibited DNA and RNA synthesis more than it inhibited protein synthesis. CN was ...

OBJECTIVE The aim of this study was to evaluate the effect of cardiac rhythm on the echocardiographic mitral valve area (MVA) and transmitral gradient calculation in relation to net atrioventricular compliance (Cn). METHODS Patients (n=22) with mild or moderate pure rheumatic mitral stenosis (MS) (MVA <2 cm2 and MVA >1 cm2) and atrial fibrillation (AF) were evaluated. All patients underwent t...