Aim Childhood chronic myeloid leukemia (CML) is rare myeloproliferative disorder, and diagnosed mostly in adult, representing for 10% of all CML, and accounts for up to 2-3% of all childhood leukemia. Tyrosine kinase inhibitor (TKI), mostly Imatinib mesylate, is now used in the frontline standard treatment of CML in chronic phase. The aim of this study is to investigate the growth effect of TKI...

There is some debate in the psychometric literature about item parameter estimation multistage designs. It occasionally argued that conditional maximum likelihood (CML) method superior to marginal (MML) because no assumptions have be made trait distribution. However, CML its original formulation leads biased estimates. Zwitser and Maris (2015, Psychometrika) proposed a modified for designs prov...

Chronic myeloid leukemia (CML) is considered a common blood cancers and accounts for approximately 15–20% of the total cases leukemia. Recent studies indicated that above 95% patients suffering CML have been found with distinctive Philadelphia chromosome originates from mutual translocation between both arms chromosomes 9 22. During this mutation ABL gene located on get transferred to breakpoin...

With the growing demands of portable devices, it is necessary to pay attention low-power digital integrated designs. This paper proposes a MOS Current Mode Logic (MCML) design, termed as Hybrid Dynamic with modified current source (H-MDyCML). In H-MDyCML circuits, functions are realized using complementary pass transistor logic which helps overcome problem stacking transistors in multiple level...

Das moglichst exakte Erfassen des Niederschlags ist ein grundlegender Bestandteil der Klima‐ und Umweltforschung sowie fur verschiedene Anwendungen, beispielsweise in Landwirtschaft. Eine neue Art Niederschlagsmessung ermoglicht das Mobilfunknetz Deutschland mittels Richtfunkstrecken (Commercial Microwave Link, CML). Der grose Vorteil dieser Methode liegt potenziell weltweit nutzbaren Infrastru...

Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that is frequently characterized by the constitutive expression of the oncogenic protein BCR-ABL tyrosine kinase. Tyrosine kinase inhibitors (TKIs) targeting breakpoint cluster region-ABL are the first-line therapy for most CML patients and have drastically improved the prognosis of CML. However, some CML patients are unrespons...

BACKGROUND The proliferation of clonal cytotoxic T-cells or natural killer cells has been observed after dasatinib treatment in small studies of patients with chronic myeloid leukemia (CML). METHODS The incidence of lymphocytosis and its association with response, survival, and side effects were assessed in patients from 3 large clinical trials. Overall, 1402 dasatinib-treated patients with n...

Bone marrow is a heterogeneous cell population which includes hematopoietic and mesenchymal progenitor cells. Dysregulated hematopoiesis occurs in chronic myelogenous leukemia (CML), being caused at least in part by abnormalities in the hematopoietic progenitors. However, the role of mesenchymal stem cells (MSCs) in CML has not been well characterized. The objectives of the present study were t...

BACKGROUND AND OBJECTIVE Altered adhesive interaction between bone marrow (BM) stroma and progenitors in chronic myeloid leukemia (CML) may be in part caused by abnormal expression of cell adhesion molecules (CAMs) on malignant progenitor cells. Treatment of CML with interferon-a (IFN-a) re-establishes normal hemopoiesis in some patients in part by restoring normal adhesive interactions between...

BACKGROUND Patients with transformed chronic myelogenous leukemia(CML) and advanced myelodysplastic syndrome(MDS) have poor prognosis. The aim of this study is to evaluate the feasibility of second chronic phase induction in accelerated phase(CML-AP) or blastic crisis of CML(CML-BC) and remission induction in advanced MDS by combining topoisomerase I inhibitor (topotecan) with topoisomerase II ...