ERS P. Barkhan, M.D., London, England T. H. Bothwell, M.D., Johannesburg, South Africa T. E. Brittingham, M.D., Nashville, Tenn. Jacque Caen, M.D., Paris, France J. B. Chatterjea, M.D., Calcutta, india Pietro deNicola, M.D., Pavia, italy Ludvik Donner, M.D., Prague, Czechoslovakia A. J. Erslev, M.D., Philadelphia H. Hugh Fudenberg, M.D., San Francisco Katsuhiro Fukutake, M.D., Tokyo, Japan Robe...

Thromb Haemost 2007; 98: 20–23 To browse through old work is a pleasure in the indian summer of a career, not devoid of nostalgia.As the large majority of our early work appeared inThrombosis and Diathesis Haemorrhagica, the present issue is an appropriate occasion to do so and to review old results, holding them against the light of our present day knowledge – and apologising beforehand for th...

As judged from thrombotest dilution curves clotting inhibiting material was present in 67% of human umbilical cord plasma samples of healthy full term infants (n = 40). The correlation coefficient (r-value) between the thrombotest clotting times and the prothrombin levels was -0.46. Using sensitive enzyme immuno assays for fibrin degradation products (FbDP) and fibrinogen degradation products (...

I T HAS BEEN postulated that in the normal individual a continuous clotting process occurs which utilizes fibrinogen to maintain normal vascular integrity.’4 This thesis has been used to account for the shorter half-life of fibrinogen as compared to other plasma proteins.54 According to this theory, individuals with severe impairment of clotting not attributable to abnorinalities involving fibr...

Although the toxic effects of citrate including hemodynamic and cardiovascular changes result from a decrease in ionized calcium levels in serum due to chelating action, these effects of citrate on blood coagulation have not yet been fully clarified. The present study examines whether serum citrate and ionized calcium levels affect whole blood clotting time in rats using the test tube method in...

INTRODUCTION This section covers the means, as far as we now know them, by which components of the blood plasma produce an insoluble protein meshwork, or gel, at a site of blood-vessel damage. The plasma is normally completely fluid, containing all its proteins in soluble form. When the clotting system is activated at a site of blood-vessel damage, a series of proteolytic reactions is set going...

Clotting systems are required in almost all animals to prevent loss of body fluids after injury. Here, we show that despite the risks associated with its systemic activation, clotting is a hitherto little appreciated branch of the immune system. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transg...

A major variable in blood coagulation tests is the nature and the amount of surface with which the blood comes in contact. When tests on recalcified plasma are used the methods of preparation and storage of the plasma have also to be considered. The prolonged contact of plasma with a large surface, e.g., with glass powder or asbestos, is accompanied by the loss of many coagulation factors, incl...

I T HAS BEEN postulated that in the normal individual a continuous clotting process occurs which utilizes fibrinogen to maintain normal vascular integrity.’4 This thesis has been used to account for the shorter half-life of fibrinogen as compared to other plasma proteins.54 According to this theory, individuals with severe impairment of clotting not attributable to abnorinalities involving fibr...